Publication: Manifestation of rs1888747 polymorphisms in the frmd3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
22119132
Other identifier(s)
2-s2.0-85109033861
Rights Holder(s)
Scopus
Bibliographic Citation
Kidney Research and Clinical Practice. Vol 40, No.2 (2021), p.263-271
Suggested Citation
Kreepala C., Panpruang P., Yodprom R., Piyajarawong T., Wattanavaekin K., Danjittrong T., Phuthomdee S. Manifestation of rs1888747 polymorphisms in the frmd3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients. Kidney Research and Clinical Practice. Vol 40, No.2 (2021), p.263-271. doi:10.23876/J.KRCP.20.190 Retrieved from: https://hdl.handle.net/20.500.14740/8024
Abstract
Background: FRMD3 polymorphisms has suggested that they could be an alternative test to differentiate diabetic nephropathy (DN) from nondiabetic renal disease (NDRD) in type 2 diabetes mellitus (DM) patients. This study was performed to investigate the relationship between the FRMD3 gene and clinical characteristics of DN. Methods: Patients who already had renal pathologic results were tested for FRMD3 polymorphisms. The subjects were classified into three groups; DN with diabetic retinopathy (DR), DN without DR, and DM with NDRD. FRMD3 polymorphisms were analyzed in each group. Results: The prevalence of GG, CG, and CC was 44.4%, 42.2%, and 13.3% respectively. There was no significant difference in clinical parameters, which consisted of disease duration, proteinuria, and complications in DN with or without DR and DM with NDRD. The G allele was mainly found in DN with DR patients (50.8%) whereas the C allele was found in DM with NDRD patients (43.5%) (p = 0.02). There was a significant association between the CC genotype in NDRD when compared to GG (p = 0.001). In addition, the C allele was 2.10-fold more often associated with NDRD than the G allele (p = 0.03). The CC genotype was correlated with risk for NDRD than the GG and GC genotypes, with odds ratios of 6.89 and 4.91, respectively (p = 0.02). Conclusion: C allele presentation, especially homozygous CC, was associated with NDRD pathology in patients with overt proteinuria. Hence, kidney biopsy is suggested in those with the C allele or homozygous CC genotype, regardless of retinopathy manifestations. © 2021 by The Korean Society of Nephrology.
Subject(s)
Creatinine
Glucose
Hemoglobin A1c
Adult
Allele
Article
Clinical feature
Controlled study
Diabetic nephropathy
Diastolic blood pressure
Disease duration
DNA extraction
End stage renal disease
Estimated glomerular filtration rate
Female
FRMD3 gene
Gene
Gene frequency
Gene mutation
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Glomerulonephritis
Hemodialysis
Human
Kidney function
Major clinical study
Male
Middle aged
Non insulin dependent diabetes mellitus
Prevalence
Proteinuria
Real time polymerase chain reaction
Single nucleotide polymorphism
Systolic blood pressure
Glucose
Hemoglobin A1c
Adult
Allele
Article
Clinical feature
Controlled study
Diabetic nephropathy
Diastolic blood pressure
Disease duration
DNA extraction
End stage renal disease
Estimated glomerular filtration rate
Female
FRMD3 gene
Gene
Gene frequency
Gene mutation
Genetic association
Genetic polymorphism
Genetic susceptibility
Genotype
Glomerulonephritis
Hemodialysis
Human
Kidney function
Major clinical study
Male
Middle aged
Non insulin dependent diabetes mellitus
Prevalence
Proteinuria
Real time polymerase chain reaction
Single nucleotide polymorphism
Systolic blood pressure