Publication: Optical Bioelectronic Device Based on a Screen-Printed Electroluminescent Transducer
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
19448244
Other identifier(s)
2-s2.0-85084663825
Rights Holder(s)
Scopus
Bibliographic Citation
ACS Applied Materials and Interfaces. Vol 12, No.20 (2020), p.22543-22551
Suggested Citation
Yakoh A., Siangproh W., Chailapakul O., Ngamrojanavanich N. Optical Bioelectronic Device Based on a Screen-Printed Electroluminescent Transducer. ACS Applied Materials and Interfaces. Vol 12, No.20 (2020), p.22543-22551. doi:10.1021/acsami.0c03812 Retrieved from: https://hdl.handle.net/20.500.14740/4553
Abstract
A new class of biosensing transducer based on alternating-current electroluminescent (ACEL) display is demonstrated. Unlike conventional ACEL displays where they have been rigidly used in flexible screens and advertising applications, here, the display is integrated with immunoassay and functioned as an optical transducer. Taking advantage of the reversed ACEL architecture, the display can be simply fabricated on an unconventional paper material without requiring the transparent indium tin oxide (ITO) electrode. The sensing mechanism relies on the promoted electronic conduction from the immunocomplex formation between immobilized antibody, antigen, and nanoparticle labeled antibody. As a result, the electroluminescence could be triggered off instantaneously. To demonstrate the device effectiveness, C-reactive protein (CRP), a particular biomarker of an inflammatory process and cardiovascular disease, is chosen as a model analyte in this work. Additionally, the applicability of the proposed platform is proved efficacious in human serums, showing negligible interference from nontargeting proteins. The sensing display is also capable of performing multiple assays (up to 8) within a single device. This bio-optoelectronic device represents a straightforward yet highly sensitive approach. This ACEL transducer is believed to explore new possibilities for biosensing and exploit in point-of-care testing. © 2020 American Chemical Society.