Publication:
Effects of long-term use of HAART on oral health status of HIV-infected subjects

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

9042512

DOI

10.1111/j.1600-0714.2009.00875.x

Other identifier(s)

2-s2.0-77951284331

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Oral Pathology and Medicine. Vol 39, No.5 (2010), p.397-406

Suggested Citation

Nittayananta W., Talungchit S., Jaruratanasirikul S., Silpapojakul K., Chayakul P., Nilmanat A., Pruphetkaew N. Effects of long-term use of HAART on oral health status of HIV-infected subjects. Journal of Oral Pathology and Medicine. Vol 39, No.5 (2010), p.397-406. doi:10.1111/j.1600-0714.2009.00875.x Retrieved from: https://hdl.handle.net/20.500.14740/7688

Title

Effects of long-term use of HAART on oral health status of HIV-infected subjects

Author(s)

Nittayananta W.
 Talungchit S.
 Jaruratanasirikul S.
 Silpapojakul K.
 Chayakul P.
 Nilmanat A.
 Pruphetkaew N.

Abstract

J Oral Pathol Med (2010) 39: 397-406 Background: The aim of this study was to determine the effects of long-term use of highly active antiretroviral therapy (HAART) on oral health status of HIV-infected subjects. Methods: Oral examination and measurement of saliva flow rate of both unstimulated and wax-stimulated whole saliva were performed in HIV-infected subjects with and without HAART, and in non-HIV individuals. The following data were recorded; duration and risk of HIV infection, type and duration of HAART, CD4 cell count, viral load, presence of orofacial pain, oral dryness, oral burning sensation, oral lesions, cervical caries, and periodontal pocket. Multiple logistic regression analysis was performed to determine the effects of long-term use of HAART on oral health status of HIV-infected subjects. Results: One hundred and fifty-seven HIV-infected subjects - 99 on HAART (age range 23-57 years, mean 39 years) and 58 not on HAART (age range 20-59 years, mean 34 years) - and 50 non-HIV controls (age range 19-59 years, mean 36 years) were enrolled. The most common HAART regimen was 2 NRTI + 2 NNRTI. HIV-infected subjects without HAART showed greater risks of having orofacial pain, oral dryness, oral lesions, and periodontal pockets than those with short-term HAART (P < 0.01). The subjects with long-term HAART were found to have a greater risk of having oral lesions than those with short-term HAART (P < 0.05). The unstimulated and stimulated salivary flow rates of the subjects with HAART were significantly lower than in those without HAART (P < 0.05). Conclusion: We conclude that long-term HAART has adverse effects on oral health status of HIV-infected subjects. © 2010 John Wiley & Sons A/S.

Subject(s)

Antiretrovirus agent
 Adult
 Age distribution
 Agglutination test
 Article
 Burning sensation
 CD4 lymphocyte count
 Controlled study
 Cross-sectional study
 Dosage schedule comparison
 Drug exposure
 Female
 Flow rate
 Gingiva bleeding
 Hairy leukoplakia
 Health status
 Highly active antiretroviral therapy
 Human
 Human immunodeficiency virus infection
 Long term care
 Major clinical study
 Male
 Mouth
 Mouth examination
 Mouth lesion
 Prevalence
 Priority journal
 Risk assessment
 Salivation
 Short course therapy
 Thrush
 Treatment duration
 Virus load
 Xerostomia
 Case control study
 Complication
 Dental caries
 Drug effects
 Health
 Health status
 Highly active antiretroviral therapy
 HIV Infections
 Middle aged
 Mouth disease
 Periodontics
 Pigmentation Disorders
 Secretion rate
 Statistical model
 Thailand
 Time
 Young adult
 Adult
 Antiretroviral Therapy, Highly Active
 Case-Control Studies
 Cross-Sectional Studies
 Dental Caries
 Female
 Health Status
 HIV Infections
 Humans
 Linear Models
 Logistic Models
 Male
 Middle Aged
 Mouth Diseases
 Oral Health
 Periodontal Index
 Pigmentation Disorders
 Salivation
 Secretory Rate
 Thailand
 Time Factors
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/7688

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Scopus: Year 1983-2021

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