Publication:
Effect of Magnesium on Glomerular Filtration Rate and Recovery of Hypertension in Women with Severe Preeclampsia

2
0

Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

16608151

DOI

10.1159/000481463

Other identifier(s)

2-s2.0-85032367027

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Nephron. Vol 138, No.1 (2018), p.35-41

Suggested Citation

Kreepala C., Luangphiphat W., Villarroel A., Kitporntheranunt M., Wattanavaekin K., Piyajarawong T. Effect of Magnesium on Glomerular Filtration Rate and Recovery of Hypertension in Women with Severe Preeclampsia. Nephron. Vol 138, No.1 (2018), p.35-41. doi:10.1159/000481463 Retrieved from: https://hdl.handle.net/20.500.14740/3761

Title

Effect of Magnesium on Glomerular Filtration Rate and Recovery of Hypertension in Women with Severe Preeclampsia

Author(s)

Kreepala C.
 Luangphiphat W.
 Villarroel A.
 Kitporntheranunt M.
 Wattanavaekin K.
 Piyajarawong T.

Abstract

Introduction: Magnesium sulfate is used for preventing seizures in patients with severe preeclampsia. Previous studies have demonstrated that magnesium plays a significant role in the endothelial function and might have clinically beneficial vasodilating properties. Objectives: This study is aimed at evaluating the effect of magnesium sulfate on the glomerular filtration rate (GFR) during the first 24 h after delivery and during the duration of recovery from hypertension in preeclampsia. Methods: Severe preeclamptic patients who had normal serum creatinine levels (0.4-0.8 mg/dL) were included in the study. Twenty-three women with severe preeclampsia were divided into groups of 9, 8, and 6, and given 1.0, 1.5, and 2.0 g/h of magnesium sulfate, respectively. Magnesium sulfate infusion was used as seizure prophylaxis for 24 h after delivery. The cystatin C-based GFR was monitored for 24 h, and the blood pressure was recorded for 12 weeks postpartum. Results: Despite the minimal improvement of GFR 24-h after treatment initiation, survival analysis demonstrated a statistically significant relationship (log rank, p = 0.04) between magnesium dosage and recovery period from hypertension. The group receiving 2.0 g/h of magnesium experienced the shortest recovery period from hypertension (6.5 ± 1.8 days). Meanwhile, the other groups required 66.0 ± 26.9 and 48.3 ± 15.6 days to recover after 1.0 and 1.5 g/h of magnesium infusion, respectively. Conclusion: Magnesium sulfate has no impact on GFR improvement during the first 24 h after delivery. However, magnesium maintenance infusion at 2.0 g/h is capable of preventing seizure by optimizing the therapeutic magnesium level (4.8-8.4 mg/dL) and shortening the hypertensive episode in preeclampsia. © 2017 S. Karger AG, Basel. Copyright: All rights reserved.

Subject(s)

Creatinine
 Cystatin C
 Magnesium sulfate
 Anticonvulsive agent
 Creatinine
 Cystatin C
 Magnesium sulfate
 Adult
 Area under the curve
 Article
 Clinical article
 Cohort analysis
 Controlled clinical trial
 Controlled study
 Creatinine blood level
 Diastolic blood pressure
 Disease severity
 Drug effect
 Female
 Gestational age
 Glomerulus filtration rate
 Human
 Infusion
 Loading drug dose
 Maintenance drug dose
 Maternal age
 Maternal hypertension
 Obstetric delivery
 Pharmacokinetic parameters
 Preeclampsia
 Priority journal
 Prophylaxis
 Puerperium
 Seizure
 Survival analysis
 Systolic blood pressure
 Blood
 Blood pressure
 Glomerulus filtration rate
 Hypertension
 Metabolism
 Pathophysiology
 Preeclampsia
 Pregnancy
 Prospective study
 Seizure
 Adult
 Anticonvulsants
 Blood Pressure
 Cohort Studies
 Creatinine
 Cystatin C
 Female
 Glomerular Filtration Rate
 Humans
 Hypertension
 Magnesium Sulfate
 Pre-Eclampsia
 Pregnancy
 Prospective Studies
 Seizures

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URI

https://hdl.handle.net/20.500.14740/3761

Collections

Scopus: Year 1983-2021

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