Publication: Molecular Mechanisms and Antidiabetic Effects of Mango (Mangifera indica) Leaf Extract as a GLP-1 Analogue in Type 2 Diabetic Rats
1
0
Issued Date
2025-12-17
Resource Type
eISSN
14220067
Scopus ID
2-s2.0-105026323974
Pubmed ID
41465578
Journal Title
International Journal of Molecular Sciences
Volume
26
Issue
24
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences Vol.26 No.24 (2025)
Suggested Citation
Jariyapongskul A., Boonsri P., Sungwienwong I., Dolsophon K., Apiratikul N., Jittangprasert P., Sitthisuk P., Rungsiwiwut R., Samosorn S., Suksamrarn S., Watanapokasin R. Molecular Mechanisms and Antidiabetic Effects of Mango (Mangifera indica) Leaf Extract as a GLP-1 Analogue in Type 2 Diabetic Rats. International Journal of Molecular Sciences Vol.26 No.24 (2025). doi:10.3390/ijms262412149 Retrieved from: https://hdl.handle.net/20.500.14740/55051
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
This study investigated the potential of scale-up mango leaf extract (MLE) as a treatment for diabetes, a global public health concern. MLE was prepared by boiling in water, yielding 12.07% (w/w), with a bioactive mangiferin content of 165.67 ± 10.88 μg/g in the crude powder. Mechanistically, MLE demonstrated a hypoglycemic effect by stimulating glucagon-like peptide-1 (GLP-1) secretion in NCI-H716 L-cells. This occurred through activation of the MAPK signaling pathway, evidenced by increased p-ERK1/2, p-p38, and p-c-Jun expression, and the Wnt signaling pathway, shown by increased β-catenin and decreased GSK-3β and Axin1 expression, consistent with molecular docking. In a type 2 diabetic rat model, MLE administration (40 mg/kg) significantly reduced metabolic parameters, including fasting blood glucose (FBG), body weight, cholesterol (CHOL), triglycerides (TGs), and HbA1c. Notably, MLE lowered serum insulin and the HOMA-IR index, and reduced serum dipeptidyl peptidase-IV (DPP-IV) levels, resulting in increased serum GLP-1, comparable to the drug sitagliptin. These findings suggest that MLE has great potential to lower blood glucose by inducing GLP-1 secretion via MAPKs and Wnt signaling pathways, positioning it as a promising candidate for alternative diabetes treatment or development as a dietary supplement.