Publication:
Strong variance in the inflammatory and cytotoxic potentials of Penicillium and Aspergillus species from cleaning workers' exposure in nursing homes

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

489697

DOI

10.1016/j.scitotenv.2020.138231

Other identifier(s)

2-s2.0-85083303299

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Science of the Total Environment. Vol 724, (2020)

Suggested Citation

Lu R., Tendal K., Frederiksen M.W., Uhrbrand K., Li Y., Madsen A.M. Strong variance in the inflammatory and cytotoxic potentials of Penicillium and Aspergillus species from cleaning workers' exposure in nursing homes. Science of the Total Environment. Vol 724, (2020). doi:10.1016/j.scitotenv.2020.138231 Retrieved from: https://hdl.handle.net/20.500.14740/4516

Title

Strong variance in the inflammatory and cytotoxic potentials of Penicillium and Aspergillus species from cleaning workers' exposure in nursing homes

Author(s)

Lu R.
 Tendal K.
 Frederiksen M.W.
 Uhrbrand K.
 Li Y.
 Madsen A.M.

Abstract

Penicillium and Aspergillus are among the dominant genera of fungi in many environments. Exposure to these fungi may cause inflammation-related health effects, however the knowledge about this at species level is limited. The aim of this study was to obtain knowledge about cleaning workers' exposure to fungi and to investigate the total inflammatory potential (TIP) and the cytotoxic potential of fungal species. The fungi were obtained from the personal exposure of cleaning workers' in five nursing homes. In total 271 fungal isolates were identified using MALDI-TOF MS. The TIP and cytotoxic potential were determined for 30 different fungal isolates covering 17 species in an in vitro assay by exposing HL-60 cells to the fungal spores of each isolate. The geometric mean exposure of the cleaning workers was 351 CFU fungi/m3 air. We showed that the TIP and cytotoxicity varied among both species and isolates. At the two lowest doses, there was a positive relationship between spore concentration and TIP. The species with highest TIPs were A. candidus and P. italicum, while the most cytotoxic ones were A. niger and A. fumigatus. There was no obvious relationship between the TIP of an isolate and its cytotoxicity. The results of this study provide a better understanding of the inflammatory potential and cytotoxicity of different environmental fungal species and contribute to the risk evaluation of exposure to different Penicillium and Aspergillus species. © 2020 Elsevier B.V.

Subject(s)

Aspergillus
 Cleaning
 Cytotoxicity
 Hospitals
 Nursing
 Fungal isolates
 Fungal species
 Geometric mean
 Health effects
 In-vitro assays
 Personal exposures
 Risk evaluation
 Workers' exposures
 Air cleaners
 Fungus
 Health impact
 Occupational exposure
 Risk assessment
 Toxicity
 Workplace
 Article
 Aspergillus
 Cleaning
 Cytotoxicity
 Dose response
 Fungus spore
 Human
 Human cell
 Low drug dose
 Matrix assisted laser desorption ionization time of flight mass spectrometry
 Niger
 Nonhuman
 Nursing home
 Occupational health
 Penicillium
 Risk assessment
 Worker
 Aspergillus
 Environmental monitoring
 Fungus
 Indoor air pollution
 Microbiology
 Nursing home
 Aspergillus
 Aspergillus candidus
 Aspergillus fumigatus
 Aspergillus niger
 Fungi
 Penicillium
 Penicillium italicum
 Air Microbiology
 Air Pollution, Indoor
 Aspergillus
 Environmental Monitoring
 Fungi
 Humans
 Niger
 Nursing Homes
 Penicillium

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URI

https://hdl.handle.net/20.500.14740/4516

Collections

Scopus: Year 1983-2021

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