Browsing Pt-Journal Articles by Subject

Now showing items 1-20 of 482

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Acanthamoeba spp. [1]
Accelerometer [1]
Acromial distance [2]
active older adults, [1]
Active stretch [1]
Activities-specific Balance Confidence Scale Thai version [1]
Adaptive/Assistive Devices [1]
adhesive capsulitis [1]
Aerobic capacity [1]
Aged [1]
Agriculture [1]
agriculturist [1]
airborne fungi [1]
Alterations in LINE-1 methylation are related to many diseases. The levels and patterns of LINE-1 hypomethylation were associated with a higher risk in developing several cancers, having a poorer prognosis and more aggressiveness. To evaluate the LINE-methylated status in psoriasis, LINE-1 methylation in various cells from patients with psoriasis, squamous cell carcinoma and normal controls were assessed by combined bisulfite restriction analysis of LINE-1. The results of the epigenetic changes for intragenic LINE-1 gene expression were also tested on two known expression microarrays. In patients with psoriasis, hypomethylation of LINE-1 and increase in %uCuC were prominent in the keratinocytes when compared with normal controls (P=0.014 and P=0.020, respectively). Alternatively, %uCmC was significantly lower in patients with severe psoriasis compared with mild psoriasis (P=0.022). The receiver-operating characteristic curve analysis indicated the high specificity and sensitivity of uCuC and uCmC in detecting psoriasis and severity of psoriasis. From expression array analysis, genes with LINE-1 were downregulated more than those genes without LINE-1 (P=3.84 × 10−27 and P=2.14 × 10−21, respectively). Modification in LINE-1 methylation may alter the gene expression resulting in a phenotypic change of the psoriatic skin. %uCuC and %uCmC may be used as biomarkers for psoriasis. [1]
Ambulatory Device [1]
anabolic steroids [1]
ankle brachial index [1]
ankle-brachial index [1]
Anterior knee pain [1]
anterior knee pain scale [1]

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