Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29232
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dc.contributor.authorSingh S.
dc.contributor.authorChidrawar V.R.
dc.contributor.authorHermawan D.
dc.contributor.authorNwabor O.F.
dc.contributor.authorOlatunde O.O.
dc.contributor.authorJayeoye T.J.
dc.contributor.authorSamee W.
dc.contributor.authorOntong J.C.
dc.contributor.authorChittasupho C.
dc.contributor.otherSrinakharinwirot University
dc.date.accessioned2023-11-15T02:08:11Z-
dc.date.available2023-11-15T02:08:11Z-
dc.date.issued2023
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85159102104&doi=10.1016%2fj.sajb.2023.04.029&partnerID=40&md5=794f2571735687416ea39e31cc9749bd
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/29232-
dc.description.abstractThis study investigated the effect of dechlorophyllization on the phytochemistry, polyphenol contents, and biological activities of Psidium guajava leaf ethanolic extracts with chlorophyll (PGE), chloroform dechlorophyllized (PGC), and sedimentation dechlorophyllized (PGS). Phytochemical profiling results demonstrated that PGE, PGC, and PGS extract contained 0.67 ± 0.01, 0.89 ± 0.03, and 0.62 ± 0.02 µg/mg of quercetin, respectively. Psidium guajava leaf extract demonstrated bacteriostatic activity against Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis with a minimum inhibitory concentration ranging from 128 to 512 µg/mL. The extract dechlorophyllized using sedimentation process significantly attenuated H2O2-induced macrophage cell mortality at 125 µg/mL, compared to PGE and PGC (250 µg/mL). Psidium guajava leaf extract, showed anti-inflammatory activity against lipopolysaccharide stimulated macrophage cells in a dose-dependent manner with IC50 values of 40.81, 91.27, and 65.54 µg/mL, respectively. Dechlorophyllized extract showed < 1% hemolysis on red blood, whereas PGE showed 5.09 ± 0.13% hemolytic effect. The cytocompatibility assay showed the IC50 values of PGC, PGS and PGE were 161.2 µg/mL, 191.2 µg/mL, and 248.2 µg/mL against oral squamous carcinoma cells. Moreover, PGE, PGC, and PGS significantly inhibited migration and colony formation of carcinoma cells. Our findings revealed that dechlorophyllization significantly impacted on the phytochemical contents and biological activities of P. guajava leaf extracts. © 2023 SAAB
dc.publisherElsevier B.V.
dc.subjectAnti-inflammatory
dc.subjectAntibacterial
dc.subjectAnticancer
dc.subjectAntimigration
dc.subjectCytocompatabilty
dc.subjectPSIDIUM guajava
dc.titleSolvent-assisted dechlorophyllization of Psidium guajava leaf extract: Effects on the polyphenol content, cytocompatibility, antibacterial, anti-inflammatory, and anticancer activities
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationSouth African Journal of Botany. Vol 158, No. (2023), p.166-179
dc.identifier.doi10.1016/j.sajb.2023.04.029
Appears in Collections:Scopus 2023

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