Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17317
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dc.contributor.authorWeecharangsan W.
dc.contributor.authorNiyomtham N.
dc.contributor.authorYingyongnarongkul B.E.
dc.contributor.authorOpanasopit P.
dc.contributor.authorLee R.J.
dc.date.accessioned2022-03-10T13:16:49Z-
dc.date.available2022-03-10T13:16:49Z-
dc.date.issued2021
dc.identifier.issn22313354
dc.identifier.other2-s2.0-85104009065
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/17317-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85104009065&doi=10.7324%2fJAPS.2021.110403&partnerID=40&md5=e3949dca145bdaedf4b4dd33e14e6a64
dc.description.abstractCholic acid-conjugated polyethylenimine 25K (PEI 25K-CA) was synthesized and characterized for gene delivery of its buffer capacity, PEI 25K-CA/plasmid DNA complex, zeta potential and particle size, transfection efficiency, cytotoxicity, and carcinoma cell growth inhibition. PEI 25K-CA was complexed with plasmid DNA at the ratio above 0.25/1. PEI 25K-CA/p53-EGFP (p53-enhanced green fluorescent protein) and PEI 25K/p53-EGFP had the particle sizes of 238.2 ± 3.1–529.1 ± 3.6 nm, and the zeta potential of 3.7 ± 1.6–4.3 ± 0.2 mV, respectively. The particle size of the complexes increased with the period of time. PEI 25K-CA/p53-EGFP had transfection efficiency as PEI 25K/ p53-EGFP. The cytotoxicity of PEI 25K-CA was dependent on the concentration of the polymer. The growth inhibition activity was dependent on the dose of p53-EGFP. PEI 25K-CA/pEGFP had better colloidal stability than PEI 25K-CA/ pEGFP. This study concluded that PEI 25K-CA had efficient gene delivery activity as PEI and had lower cytotoxicity and more colloidal stability than PEI 25K. © 2021 Wanlop Weecharangsan et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
dc.languageen
dc.titleGrowth inhibition of cholic acid-conjugated polyethylenimine 25K/ p53-EGFP complexes on human carcinoma cells
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Applied Pharmaceutical Science. Vol 11, No.4 (2021), p.14-21
dc.identifier.doi10.7324/JAPS.2021.110403
Appears in Collections:Scopus 1983-2021

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