Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15217
Title: A herbal medicine used in the treatment of addiction mimics the action of amphetamine on in vitro rat striatal dopamine release
Authors: Thongsaard W.
Marsden C.A.
Keywords: amphetamine
dopamine
plant extract
potassium ion
simplocos racemosa extract
thunbergia laurifolia extract
unclassified drug
amphetamine
dopamine
plant extract
plant medicinal product
addiction
animal tissue
article
brain slice
controlled study
corpus striatum
dopamine release
drug effect
drug mechanism
drug potency
electrochemical detection
herbal medicine
high performance liquid chromatography
in vitro study
male
neurotransmission
nonhuman
priority journal
rat
addiction
animal
biosynthesis
chemistry
comparative study
isolation and purification
metabolism
methodology
phytotherapy
plant leaf
secretion
Wistar rat
Amphetamine
Animal
Comparative Study
Corpus Striatum
Dopamine
Male
Phytotherapy
Plant Extracts
Plant Leaves
Plant Preparations
Rats
Rats, Wistar
Substance-Related Disorders
Support, Non-U.S. Gov't
Animals
Male
Plant Extracts
Plant Leaves
Rats
Rats, Wistar
Issue Date: 2002
Abstract: Thunbergia laurifolia Linn. (TH) and Simplocos racemosa Roxb. (SY) are herbal medicines used in the treatment of drug addiction without scientific support for their mechanism of action. The present study investigated the effects of these medicinal plants on dopaminergic neurotransmission in comparison with amphetamine. The effect of crude water extracts (0.1 g/ml) of TH and SY on K+ (20 mM)-stimulated dopamine release from rat striatal slices were compared with amphetamine (10-4 M) using high-performance liquid chromatography with electrochemical detection to measure endogenous dopamine. Amphetamine and TH, but not SY, significantly increased K+-stimulated dopamine release (P<0.001) from rat striatal slices when compared with K+-stimulated alone. TH potentiated the effect of amphetamine on K+-stimulated dopamine release (P<0.001) when compared with amphetamine alone. The results indicate that TH may stimulate dopamine release in the same manner as amphetamine. It remains to be determined whether the effect of these extracts on dopamine function is important in their therapeutic use in the treatment of drug addiction. © 2002 Published by Elsevier Science Ireland Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037199652&doi=10.1016%2fS0304-3940%2802%2900658-4&partnerID=40&md5=dc3296f7f9c486ea5204650abe5eada4
http://ir.swu.ac.th/jspui/handle/123456789/15217
ISSN: 3043940
Appears in Collections:SCOPUS 1983-2021

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