Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15122
Title: Comparing the effect of short term post meals and bedtime calcium supplementation on the C-terminal telopeptide crosslinks and PTH levels in postmenopausal osteopenic women.
Authors: Chuengsamarn S.
Suwanwalaikorn S.
Keywords: bone density conservation agent
collagen type 1
collagen type I trimeric cross linked peptide
collagen type I trimeric cross-linked peptide
parathyroid hormone
peptide
PTH protein, human
aged
article
blood
calcium intake
clinical trial
comparative study
controlled clinical trial
controlled study
crossover procedure
diet supplementation
double blind procedure
drug administration
female
human
middle aged
postmenopause osteoporosis
postprandial state
randomized controlled trial
Aged
Bone Density Conservation Agents
Calcium, Dietary
Collagen Type I
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Drug Administration Schedule
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal
Parathyroid Hormone
Peptides
Postprandial Period
Issue Date: 2005
Abstract: BACKGROUND: Calcium supplement for postmenopausal osteopenic women can significantly reduce bone loss and the risk of fractures. However, the optimal time for calcium supplementation remains controversial. OBJECTIVE: The aim of the present study was to compare the effect of twice daily post meals and bedtime calcium supplementation for a two week periods, on C-terminal telopeptide crosslinks and PTH levels in postmenopausal osteopenic women. DESIGN: A randomized double blind placebo-control, crossover design, was carried out on 3 consecutive periods 3 of a 2-week treatment regimen. In the first period, all the subjects randomly received either two calcium carbonate tablets (Chalk Cap all subjects randomly received either two calcium 334 mg per tab) or placebo at bedtime with one tablet of calcium tablet or placebo after breakfast and dinner for two weeks. In the second period, subjects received only placebo tablets after the meals and at bedtime for 2 weeks. In the third period subjects received either calcium carbonate or placebo for another two weeks. The C-terminal telopeptide crosslinks were measured at 8.00 am and serum PTH were sampled at 8 time points (12.00 am, 2.00 am, 4.00 am, 6.00 am, 8.00 am, 9.00 am, 5.00 pm, and 7.00 pm respectively by the end of each study at the first and third period. RESULTS: The present study showed thirty-six postmenopausal subjects (mean age 63.9 + 3.66 years) participated in the present study. The mean T-score BMD of the spine and hip were -2.96 + 0.87 and -2.96 + 0.77 gm/cm2. C-terminal telopeptide crosslinks levels of the bedtime supplementation were significantly lower than the post meal supplementation (0.228 + 0.002 ng/ml vs 0.313 + 0.003 ng/ml, p < 0.001). The mean night time serum PTH level during the bedtime was significantly lower than the post meal period. (25.17 + 2.31 pg/ml vs 31.930 + 2.677 pg/ml, p < 0.001). No differences in the post meal PTH level between two periods were observed CONCLUSION: The bedtime calcium supplementation appeared to reduce the bone resorption marker and night time serum PTH levels greater than the post meal calcium supplementation in this short term period study. However, long term comparison may be needed.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15122
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33748475514&partnerID=40&md5=2185e99e1460433a41d44433bb79ceb2
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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