Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/15120
Title: Novel activities of 1-Adamantylthiopyridines as antibacterials, antimalarials and anticancers
Authors: Prachayasittikul S.
Treeratanapiboon L.
Ruchirawat S.
Prachayasittikul V.
Issue Date: 2009
Abstract: To discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 μg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and β-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 μg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349916584&partnerID=40&md5=9c9073509cdea897f11eda3760694e7c
http://ir.swu.ac.th/jspui/handle/123456789/15120
ISSN: 16112156
Appears in Collections:SCOPUS 1983-2021

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