Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14863
Title: Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology
Authors: Tripanichkul W.
Jaroensuppaperch E.-o.
Finkelstein D.I.
Keywords: estradiol
glial fibrillary acidic protein
lectin
tyrosine 3 monooxygenase
animal cell
animal experiment
animal tissue
article
cell count
cell structure
controlled study
dopaminergic nerve cell
drug effect
glia cell
male
mouse
nonhuman
priority journal
substantia nigra
Animals
Cell Count
Cell Proliferation
Cell Size
Dopamine
Estradiol
Estrogens
Glial Fibrillary Acidic Protein
Glycoproteins
Male
Mice
Mice, Inbred C57BL
Neuroglia
Neurons
Substantia Nigra
Tyrosine 3-Monooxygenase
Issue Date: 2008
Abstract: Emerging evidence indicate the modulating effects of estrogen on dopaminergic neurons in the substantia nigra pars compacta (SNpc). One of the mechanisms underlying the effect of estrogen is through neuroglia. To determine whether estrogen affects the number of dopaminergic neurons and reactive astrocytes and microglia in the SNpc of male mice, 14-week-old C57Bl/6 male mice were injected with 17β-estradiol (E2) or vehicle for 10.5 days. On day 11 all mice were killed and the SNpc were collected and processed for lectin (GSI-B4) histochemistry, tyrosine hydroxylase (TH) immunohistochemistry or glial fibrillary acidic protein (GFAP) immunohistochemistry. Quantitative studies demonstrated that E2 significantly increases the number of TH-immunoreactive (IR) neurons in the SNpc but the hormone induces no change either in cell number or cell morphology of GFAP-IR astroglia and GSI-B4+ve microglia. These observations suggest that E2 can influence the number of nigral dopaminergic neurons of male mice and possibly protects dopaminergic neuronal loss during normal aging and in Parkinson's disease. © 2008 Elsevier Ireland Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-41549112790&doi=10.1016%2fj.neulet.2008.02.038&partnerID=40&md5=9415acc34b732b119b92e664f657c248
http://ir.swu.ac.th/jspui/handle/123456789/14863
ISSN: 3043940
Appears in Collections:Scopus 1983-2021

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