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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14853
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dc.contributor.authorYingyongnarongkul B.-E.
dc.contributor.authorApiratikul N.
dc.contributor.authorAroonrerk N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:31:59Z-
dc.date.available2021-04-05T04:31:59Z-
dc.date.issued2008
dc.identifier.issn2536269
dc.identifier.other2-s2.0-45749097459
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14853-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-45749097459&doi=10.1007%2fs12272-001-1215-4&partnerID=40&md5=9d9df22ae5f6bc2755552008dc25c54d
dc.description.abstractBis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl) polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells. © 2008 The Pharmaceutical Society of Korea.
dc.subject3,4-dihydroxyphenylpropionic acid
dc.subjectantiinfective agent
dc.subjectcaffeic acid derivative
dc.subjectdihydrocaffeic acid
dc.subjectdrug derivative
dc.subjectspermidine
dc.subjectanimal
dc.subjectantibiotic resistance
dc.subjectarticle
dc.subjectcell survival
dc.subjectCercopithecus
dc.subjectchemical structure
dc.subjectdose response
dc.subjectdrug effect
dc.subjectgrowth, development and aging
dc.subjectIC 50
dc.subjectmicrobiological examination
dc.subjectpenicillin resistance
dc.subjectStaphylococcus aureus
dc.subjectsynthesis
dc.subjectVero cell
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectCaffeic Acids
dc.subjectCell Survival
dc.subjectCercopithecus aethiops
dc.subjectDose-Response Relationship, Drug
dc.subjectInhibitory Concentration 50
dc.subjectMethicillin Resistance
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectSpermidine
dc.subjectStaphylococcus aureus
dc.subjectVancomycin Resistance
dc.subjectVero Cells
dc.titleSynthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationArchives of Pharmacal Research. Vol 31, No.6 (2008), p.698-704
dc.identifier.doi10.1007/s12272-001-1215-4
Appears in Collections:Scopus 1983-2021

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