Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14728
Title: Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds
Authors: Pingaew R.
Prachayasittikul S.
Ruchirawat S.
Keywords: antimalarial agent
antineoplastic agent
isoquinoline derivative
thiosemicarbazone derivative
article
cell death
chemistry
drug effect
human
Plasmodium falciparum
synthesis
tumor cell line
Antimalarials
Antineoplastic Agents
Cell Death
Cell Line, Tumor
Humans
Isoquinolines
Plasmodium falciparum
Thiosemicarbazones
Issue Date: 2010
Abstract: Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarbazones 1-5 displayed cytotoxicity toward all the tested cell lines, while compounds 2-5 selectively showed potent activity against the MOLT-3 cell lines. Significantly, N(4)-phenyl-2-benzoylpyridine thiosemicarbazone 4 exhibited the most potent activity against HuCCA-1, HepG2, A549 and MOLT-3 cell lines with IC50 values of 0.03, 4.75, 0.04 and 0.004 μg/mL, respectively. In addition, 2-benzoylpyridine thiosemicarbazones 3 and 4 showed antimalarial activity against Plasmodium falciparum with IC 50 of 10-7 to < 10-6 M. The study demonstrates the quite promising activity of analog 4 as a lead molecule for further development. © 2010 by the authors.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77649206777&doi=10.3390%2fmolecules15020988&partnerID=40&md5=759ed2e7755d636fef97c83c395b6aa5
http://ir.swu.ac.th/jspui/handle/123456789/14728
ISSN: 14203049
Appears in Collections:SCOPUS 1983-2021

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