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Title: Stem cell based therapy in the inner ear: Appropriate donor cell types and routes for transplantation
Authors: Jongkamonwiwat N.
Zine A.
Rivolta M.N.
Keywords: ciliary neurotrophic factor
neurogenin 1
neurotrophic factor
cell type
cochlea duct
cochlea prosthesis
cochlear nerve
cochlear nucleus
Corti organ
ear protection
embryonic stem cell
hearing impairment
inner ear
mesenchymal stem cell
mesenchymal stem cell transplantation
neural stem cell
pluripotent stem cell
protein expression
spiral ganglion
stem cell transplantation
surgical technique
Cochlear Implantation
Hair Cells, Auditory
Models, Anatomic
Nerve Growth Factors
Sensory Receptor Cells
Stem Cell Transplantation
Stem Cells
Issue Date: 2010
Abstract: Losing one of our main sensory systems such as hearing can have devastating consequences in the way we interact with the world. The main problem lies in the fact that the critical sensory cells, the auditory neurons and hair cells located in the cochlea are only generated during development and, when damaged, cannot be replaced. The options currently available to treat this condition are very limited, and are mostly represented by prosthetic devices such as hearing aids and cochlear implants. There is a clear need for a therapeutic breakthrough that will help the millions of people affected, and the advances in stem cell technologies are offering a glimmer of hope for this affliction. Although still at a very early stage, a growing bulk of literature is being produced attempting to pave the path for a stem cell-based therapy for deafness. From the many variables to bear in mind when developing this approach, two appear to be of paramount importance. First, different cell types are potentially to be used, all of them having advantages and disadvantages. Second, in order to target such a small and secluded organ as the cochlea, difficult surgical techniques are to be used, some of which still need to be developed. The present article will aim to present the most recent advances of the field, focussing on these two critical issues. © 2010 Bentham Science Publishers Ltd.
ISSN: 13894501
Appears in Collections:SCOPUS 1983-2021

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