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Title: 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus
Authors: Lawung R.
Treeratanapiboon L.
Prachayasittikul S.
Prachayasittikul V.
Keywords: 3 (1 adamantylthio) 4 phenylpyridine
5 (1 adamantylthio) 3 picoline
antibiotic agent
pyridine derivative
unclassified drug
animal cell
antibacterial activity
cell viability
controlled study
dose response
IC 50
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
priority journal
Issue Date: 2010
Abstract: In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic. © 2010 Bentham Science Publishers Ltd.
ISSN: 15701808
Appears in Collections:SCOPUS 1983-2021

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