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|Title:||Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea|
absence of side effects
controlled clinical trial
double blind procedure
length of stay
major clinical study
randomized controlled trial
Length of Stay
|Abstract:||Introduction: Probiotics have demonstrated potential to reduce duration of diarrhoea and frequency of watery stools. Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum (Infloran®) are usually maintained at a storage temperature of 4°C which is generally not feasible in tropical or sub-tropical countries. Aim: The efficacy of Infloran® for treatment of acute diarrhoea when stored at 28-32°C (room temperature) was evaluated. Methods: This was a double-blind, randomised study of infants and children aged 2 months to 7 years with acute diarrhoea. Patients were randomly assigned to receive Infloran® stored at 4°C, at room temperature, or to a placebo group. Duration of diarrhoea was a primary outcome, while the number of stools, hospital stay and requirement for rehydration fluid were secondary outcomes. Results: Probiotics shortened duration of diarrhoea (34.1 and 34.8 hrs when stored either at 4°C or at room temperature, respectively, and 58 hrs with placebo, p<0.01) and reduced the number of stools (7.3 and 8 vs 15.9 with placebo, p<0.01). Conclusion: Administration of probiotics is beneficial as additional treatment of acute diarrhoea and efficacy is not affected by storage temperature. © 2010 W. S. Maney & Son Ltd.|
|Appears in Collections:||Scopus 1983-2021|
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