Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14641
Title: Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea
Authors: Rerksuppaphol S.
Rerksuppaphol L.
Keywords: infloran
placebo
probiotic agent
unclassified drug
absence of side effects
acute diarrhea
article
Bifidobacterium bifidum
child
clinical trial
controlled clinical trial
controlled study
disease duration
double blind procedure
drug efficacy
drug storage
environmental temperature
feces analysis
female
human
infant
Lactobacillus acidophilus
length of stay
major clinical study
male
preschool child
randomized controlled trial
rehydration
school child
Acute Disease
Bifidobacterium
Child
Child, Preschool
Diarrhea
Diarrhea, Infantile
Double-Blind Method
Feces
Female
Humans
Infant
Lactobacillus acidophilus
Length of Stay
Male
Probiotics
Refrigeration
Temperature
Time Factors
Treatment Outcome
Issue Date: 2010
Abstract: Introduction: Probiotics have demonstrated potential to reduce duration of diarrhoea and frequency of watery stools. Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum (Infloran®) are usually maintained at a storage temperature of 4°C which is generally not feasible in tropical or sub-tropical countries. Aim: The efficacy of Infloran® for treatment of acute diarrhoea when stored at 28-32°C (room temperature) was evaluated. Methods: This was a double-blind, randomised study of infants and children aged 2 months to 7 years with acute diarrhoea. Patients were randomly assigned to receive Infloran® stored at 4°C, at room temperature, or to a placebo group. Duration of diarrhoea was a primary outcome, while the number of stools, hospital stay and requirement for rehydration fluid were secondary outcomes. Results: Probiotics shortened duration of diarrhoea (34.1 and 34.8 hrs when stored either at 4°C or at room temperature, respectively, and 58 hrs with placebo, p<0.01) and reduced the number of stools (7.3 and 8 vs 15.9 with placebo, p<0.01). Conclusion: Administration of probiotics is beneficial as additional treatment of acute diarrhoea and efficacy is not affected by storage temperature. © 2010 W. S. Maney & Son Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-78649677081&doi=10.1179%2f146532810X12858955921159&partnerID=40&md5=730b8347612936b62a6d802f02035090
http://ir.swu.ac.th/jspui/handle/123456789/14641
ISSN: 2724936
Appears in Collections:Scopus 1983-2021

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