Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14436
Title: Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels
Authors: Panaree B.
Chantana M.
Wasana S.
Chairat N.
Keywords: brain derived neurotrophic factor
cholesterol
high density lipoprotein cholesterol
hydrocortisone
low density lipoprotein cholesterol
triacylglycerol
brain derived neurotrophic factor
hydrocortisone
lipid
adult
age
apnea hypopnea index
article
body height
body mass
body weight
chemoluminescence
cholesterol blood level
clinical article
colorimetry
controlled study
enzyme linked immunosorbent assay
female
gender
human
hydrocortisone blood level
male
polysomnography
priority journal
protein blood level
sleep apnea syndrome
triacylglycerol blood level
blood
middle aged
reference value
sleep apnea syndrome
Thailand
university hospital
Academic Medical Centers
Adult
Brain-Derived Neurotrophic Factor
Female
Humans
Hydrocortisone
Lipids
Male
Middle Aged
Polysomnography
Reference Values
Sleep Apnea, Obstructive
Thailand
Issue Date: 2011
Abstract: Objectives: Obstructive sleep apnea (OSA) is a sleep-disordered breathing leading to vascular endothelial cells dysfunction, cognitive impairment, and abnormal lipid metabolism. serum brain-derived neurotrophic factor (BDNF) protein, cortisol, and lipid levels in OSA were investigated. Materials and methods: All middle-aged subjects including healthy individuals without signs and symptoms of apneahypopnea and ear nose throat (ENT) outpatients were randomly recruited and screened by overnight polysomnogram (PSG). Apnea-hypopnea index (AHI) was used as a criteria to determine subjects to enroll in this program. According to AHI, they were separated into control and OSA groups. A group of 39 OSA patients (AHI≥10 events/h) and 24 control subjects (AHI<5 events/h) were selected. Serum BDNF protein was analyzed by enzyme-linked immunosorbent assay (ELISA) from venous blood collection at 8:00 a.m. following PSG. Serum cortisol was assayed by enzyme-chemiluminescense immuno assay (ECLIA). Serum lipid profile levels were determined by enzymatic colorimetric and homogeneous method. Results: Characteristics of OSA patients and control groups including gender, age, AHI, body weight, height, and BMI showed significant differences. Serum BDNF protein, cortisol, triglyceride, and total cholesterol levels in OSA and control groups were not significantly different. High density lipoprotein-cholesterol (HDL-c) in OSA was significantly lower than that of control (p=0.008) while low density lipoprotein-cholesterol (LDL-c) was significantly higher than that of control (p=0.04). Conclusions: OSA had no significant effect on serum BDNF, cortisol, triglyceride, or total cholesterol levels while LDL-c and HDL-c levels in OSA patients compared to control were significantly different at p=0.04, and p= 0.008, respectively. © Springer-Verlag 2010.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859389181&doi=10.1007%2fs11325-010-0415-7&partnerID=40&md5=9d13f655ad60fc7ff6911f776adb8285
http://ir.swu.ac.th/jspui/handle/123456789/14436
ISSN: 15209512
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.