Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14267
Title: Randomized controlled trial of probiotics to reduce common cold in schoolchildren
Authors: Rerksuppaphol S.
Rerksuppaphol L.
Keywords: placebo
probiotic agent
absenteeism
adolescent
antibiotic therapy
article
bacterial strain
Bifidobacterium bifidum
child
clinical article
common cold symptom
controlled study
coughing
diarrhea
double blind procedure
fever
human
Lactobacillus acidophilus
priority journal
randomized controlled trial
rhinorrhea
risk factor
school child
treatment outcome
vomiting
winter
Adolescent
Bifidobacterium
Child
Common Cold
Double-Blind Method
Female
Humans
Lactobacillus acidophilus
Male
Population
Probiotics
Thailand
Treatment Outcome
Issue Date: 2012
Abstract: Background: The common cold is responsible for the largest proportion of school and work absenteeism and causes a huge economic burden. None of the current interventions is greatly effective for prevention. Our aim was to assess the efficacy of a two-strain combination probiotic for prevention of common cold symptoms in healthy schoolchildren. Methods: A double-blind randomized controlled trial was performed during the winter season in a public school of central Thailand. Children, aged 8-13 years, were randomized to receive either a two-strain combination probiotic (Lactobacillus acidophilus and Bifidobacterium bifidum) or placebo given twice a day for 3 months. The primary outcome was any symptom of cold during the 3-month study period while vomiting, diarrhea, use of antibiotics, school absence due to any cause, school absence due to cold and duration of all symptoms were secondary outcomes. Results: Of the 40 children in each group, 31 (77%) in the probiotic group, compared to 38 (95%) in the placebo group (P= 0.048), developed at least one symptom of cold. Children in the probiotics group had significantly lower risk of fever, cough, rhinorrhea, school absence and school absence related to common cold compared to children in the placebo group. There was no impact on diarrhea and vomiting. Conclusion: A two-strain probiotic combination given twice a day for 3 months was able to reduce the symptoms of the common cold and school absenteeism in schoolchildren. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867026187&doi=10.1111%2fj.1442-200X.2012.03647.x&partnerID=40&md5=6fd0b3a16589a07be133f3997847a4be
http://ir.swu.ac.th/jspui/handle/123456789/14267
ISSN: 13288067
Appears in Collections:Scopus 1983-2021

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