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Title: Biomedical and clinical promises of human pluripotent stem cells for neurological disorders
Authors: Jongkamonwiwat N.
Noisa P.
Keywords: biomedicine
brain disease
cell therapy
drug screening
motor neuron disease
multiple sclerosis
nerve cell
neurologic disease
organ donor
Parkinson disease
pluripotent stem cell
spinal cord injury
stem cell
stem cell transplantation
degenerative disease
disease model
nerve cell
neural stem cell
Disease Models, Animal
Neural Stem Cells
Neurodegenerative Diseases
Pluripotent Stem Cells
Stem Cell Transplantation
Issue Date: 2013
Abstract: Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders. © 2013 Nopporn Jongkamonwiwat and Parinya Noisa.
ISSN: 23146133
Appears in Collections:SCOPUS 1983-2021

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