Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13966
Title: Comparative trial of moisturizer containing spent grain wax, Butyrospermum parkii Extract, Argania spinosa kernel oil vs. 1% hydrocortisone cream in the treatment of childhood atopic dermatitis
Authors: Jirabundansuk P.
Ophaswongse S.
Udompataikul M.
Keywords: Argania spinosa kernel oil
Butyrospermum parkii extract
dermatological agent
hydrocortisone
plant extract
plant medicinal product
spent grain wax
unclassified drug
wax
hydrocortisone
hydrocortisone acetate
adolescent
Article
atopic dermatitis
child
clinical article
controlled study
disease severity
drug efficacy
dry skin
edema
erythema
excoriation
female
follow up
human
lichenoid eruption
male
outcome assessment
patient satisfaction
randomized controlled trial
relapse
remission
scoring of Atopic Dermatitis
scoring system
skin injury
analogs and derivatives
cereal
chemistry
comparative study
Dermatitis, Atopic
intradermal drug administration
preschool child
recurrent disease
Sapotaceae
severity of illness index
single blind procedure
treatment outcome
Administration, Cutaneous
Cereals
Child
Child, Preschool
Dermatitis, Atopic
Female
Humans
Hydrocortisone
Male
Recurrence
Sapotaceae
Severity of Illness Index
Single-Blind Method
Treatment Outcome
Issue Date: 2014
Abstract: Objective: To compare an efficacy of a moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania spinosa kernel oil (S) with 1% hydrocortisone cream (HC) for the treatment of mild to moderate atopic dermatitis.Material and Method: Twenty-nine patients, age between 2 and 15 years old with mild to moderate atopic dermatitis were enrolled. The body was randomly divided to left and right side. One side was applied with S cream and the other side was applied with HC cream twice daily for four weeks. Observation of recurrence rate after remission was recorded. Clinical outcomes were analyzed by using the scoring of Atopic Dermatitis (SCORAD) score. Statistical analysis was done by using descriptive statistics, pair t-test, one-way repeated ANOVA, and McNemar’s test.Results: It was demonstrated that both agents had improvement of SCORAD score after two weeks, with statistically significant difference (p<0.001). At fourth week, both agents had improvement of SCORAD score without being statistically significant different (p>0.05). Although the S cream side had higher remission rate than the HC cream side, there was no statistically significant difference (p>0.05).Conclusion: S cream was as effective as HC cream in the treatment and maintenance period of mild to moderate childhood atopic dermatitis. © 2014 Medical Association of Thailand. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908606837&partnerID=40&md5=72b39f6ae808a15a9a205c5277a5e5e9
http://ir.swu.ac.th/jspui/handle/123456789/13966
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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