Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13839
Title: Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract
Authors: Asasutjarit R.
Larpmahawong P.
Fuongfuchat A.
Sareedenchai V.
Veeranondha S.
Keywords: alpha mangostin rich extract
anti acne agent
antiinfective agent
citric acid triethyl ester
dichloromethane
eudragit
hydroxypropylcellulose
irritant agent
plasticizer
polymer
unclassified drug
antiinfective agent
mangostin
plant extract
solution and solubility
xanthone derivative
acne vulgaris
antibacterial activity
article
bacterial growth
cell membrane
column chromatography
dialysis membrane
disk diffusion
drug formulation
drug release
elasticity
film forming solution
flow kinetics
hardness
high performance liquid chromatography
higuchi equation
human
human cell
hydrogen bond
hydrophobicity
infrared spectroscopy
mathematical model
minimum inhibitory concentration
MTT assay
newtonian flow
pH
physical chemistry
phytochemistry
priority journal
Propionibacterium acnes
scanning electron microscopy
shear stress
skin fibroblast
skin irritation
surface property
tensile strength
thin layer chromatography
viscosity
chemistry
drug effects
Garcinia mangostana
microbial sensitivity test
Propionibacterium acnes
solution and solubility
Anti-Bacterial Agents
Chromatography, Thin Layer
Garcinia mangostana
Microbial Sensitivity Tests
Plant Extracts
Propionibacterium acnes
Solutions
Spectroscopy, Fourier Transform Infrared
Xanthones
Issue Date: 2014
Abstract: The objective of this study was to study the effect of formulation compositions on physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract (AM). Film-forming solution bases and film-forming solutions containing AM were prepared by using Eudragit RL PO or Klucel LF or combinations of them as film-forming polymers. Rheological properties, pH values of the solutions, and mechanical properties of the dry films were investigated. An optimized formulation was selected and evaluated for the film surface, in vitro AM release, an anti-P. acnes activity, and potential for being a skin irritant. It was found that mechanical properties of the dry films were affected by total polymer contents, ratios of Klucel LF/Eudragit RL PO, AM, and contents of triethyl citrate. The film-forming solutions containing AM had pH values around 7.0. Their flow curves exhibited Newtonian flow behaviors. The optimized formulation provided films possessing smooth and nonporous surfaces. These films showed greater anti-P. acnes activity than their base films without toxicity to skin fibroblasts. Furthermore, AM released from the film matrix obeyed Higuchi's equation. In conclusion, the film-forming solutions containing AM had potential for treatment of acne vulgaris caused by P. acnes. However, further in vivo study is necessary to determine their efficacy and safety for using in patients suffering from acne vulgaris. © 2013 American Association of Pharmaceutical Scientists.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898052782&doi=10.1208%2fs12249-013-0057-8&partnerID=40&md5=afe117e1898726dd8d9c9c1c4ce7b89c
http://ir.swu.ac.th/jspui/handle/123456789/13839
ISSN: 15309932
Appears in Collections:SCOPUS 1983-2021

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