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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13798
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dc.contributor.authorArunrattiyakorn P.
dc.contributor.authorSuwannasai N.
dc.contributor.authorAree T.
dc.contributor.authorKanokmedhakul S.
dc.contributor.authorIto H.
dc.contributor.authorKanzaki H.
dc.date.accessioned2021-04-05T03:32:26Z-
dc.date.available2021-04-05T03:32:26Z-
dc.date.issued2014
dc.identifier.issn13811177
dc.identifier.other2-s2.0-84896280271
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13798-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896280271&doi=10.1016%2fj.molcatb.2014.02.010&partnerID=40&md5=a30cd03964204fad2d898a40f5a87983
dc.description.abstractThe microbial transformation of the major mangosteen pericarp xanthone, α-mangostin (1) by the endophytic fungi Colletotrichum sp. MT02 and Phomopsis euphorbiae K12 resulted in the production of the five metabolites 2-6. Biotransformation with Colletotrichum sp. MT02 converted 1 into 17,18-dihydroxymangostanin (2) and cyclomangostanin (3), while incubation with P. euphorbiae K12 gave 12,13,20-trihydroxymangostin (4), 12,13,19- trihydroxymangostin (5), and 20-hydroxymangostanin (6) as transformation products. The structures of these metabolites were elucidated via spectroscopic analyses, and for compound 3, the structure was confirmed by X-ray crystallographic analysis. All metabolites are new, and metabolite 3 possessed an unusual structure of bis-ring fused xanthene in nature. In addition, substrate and all products were evaluated for the antimycobacterial activity against Mycobacterium tuberculosis as well as the cytotoxicity against breast cancer (MCF-7) cell lines. © 2014 Elsevier B.V.
dc.subjectBioconversion
dc.subjectBiomolecules
dc.subjectCell culture
dc.subjectSpectroscopic analysis
dc.subjectX ray crystallography
dc.subjectAntimycobacterial activity
dc.subjectBiotransformation
dc.subjectColletotrichum sp
dc.subjectMicrobial transformation
dc.subjectMycobacterium tuberculosis
dc.subjectPhomopsis
dc.subjectPrenylated xanthone
dc.subjectX-ray crystallographic analysis
dc.subjectMetabolites
dc.subject12,13,19 trihydroxymangostin
dc.subject12,13,20 trihydroxymangostin
dc.subject17,18 dihydroxymangostanin
dc.subject20 hydroxymangostanin
dc.subjectalpha mangostin
dc.subjectantiinfective agent
dc.subjectcyclomangostanin
dc.subjectdoxorubicin
dc.subjecttamoxifen
dc.subjectunclassified drug
dc.subjectxanthone derivative
dc.subjectantimicrobial activity
dc.subjectarticle
dc.subjectbiotransformation
dc.subjectcarbon nuclear magnetic resonance
dc.subjectColletotrichum
dc.subjectcytotoxicity
dc.subjectenzyme structure
dc.subjectenzyme substrate
dc.subjectenzyme synthesis
dc.subjectfungal strain
dc.subjectfungus
dc.subjectfungus isolation
dc.subjectGarcinia mangostana
dc.subjectIC 50
dc.subjectincubation time
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectolive tree
dc.subjectPhomopsis euphorbiae
dc.subjectproton nuclear magnetic resonance
dc.subjectX ray crystallography
dc.titleBiotransformation of α-mangostin by Colletotrichum sp. MT02 and Phomopsis euphorbiae K12
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Molecular Catalysis B: Enzymatic. Vol 102, (2014), p.174-179
dc.identifier.doi10.1016/j.molcatb.2014.02.010
Appears in Collections:Scopus 1983-2021

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