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https://ir.swu.ac.th/jspui/handle/123456789/13796| Title: | Anti-Helicobacter pylori xanthones of Garcinia fusca |
| Authors: | Nontakham J. Charoenram N. Upamai W. Taweechotipatr M. Suksamrarn S. |
| Keywords: | antiinfective agent xanthone derivative chemistry drug effects Garcinia Helicobacter pylori isolation and purification mass spectrometry microbial sensitivity test nuclear magnetic resonance spectroscopy plant root Anti-Bacterial Agents Garcinia Helicobacter pylori Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Plant Roots Xanthones |
| Issue Date: | 2014 |
| Abstract: | A new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (2-9 and 11), a biphenyl (10) and three biflavonoids (12-14) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 11-14 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin. © 2013 The Pharmaceutical Society of Korea. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13796 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886913190&doi=10.1007%2fs12272-013-0266-4&partnerID=40&md5=6680d89608ae6dcaf2bfa5fb4daf7ed2 |
| ISSN: | 2536269 |
| Appears in Collections: | Scopus 1983-2021 |
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