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Title: Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents
Authors: Prachayasittikul S.
Pingaew R.
Worachartcheewan A.
Sinthupoom N.
Prachayasittikul V.
Ruchirawat S.
Prachayasittikul V.
Keywords: 1,2,3 triazole derivative
1,4 naphthoquinone
2,4 diphenoxy 6 aryl pyridine
2,4 diphenoxy pyridine
2,4 diphenoxyl 6 heteroaryl pyridine
2,4 diphenyl 6 aryl pyridine
2,4 diphenyl 6 heteroaryl pyridine
2,4,6 triheteroaryl pyridine
2,4,6 triphenyl pyridine
2,6 diaminopyridine
2,6 diphenyl 4 heteroaryl pyridine
3 aminopicolinaldehyde thiosemicarbazone
3 aminopyridine thiosemicarbazone
3,5 disubstituted pyridine
4 chromanone derivative
anthranilic acid
antineoplastic agent
picoline derivative
pyridine derivative
pyrimidine derivative
ribonucleotide reductase
thiadiazole derivative
thiosemicarbazone derivative
unclassified drug
unindexed drug
antineoplastic agent
pyridine derivative
pyrimidine derivative
A-549 cell line
antineoplastic activity
antiproliferative activity
breast cancer
cancer cell
cancer therapy
cell growth
cell survival
chronic myeloid leukemia
colorectal cancer
DNA repair
erectile dysfunction
Hep-G2 cell line
kidney carcinoma
non small cell lung cancer
prostate cancer
quality of life
tumor suppressor gene
DNA damage
drug effects
structure activity relation
Antineoplastic Agents
Cell Survival
DNA Damage
Structure-Activity Relationship
Issue Date: 2017
Abstract: Background: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing drugs have driven the search for novel anticancer drugs with better potency and selectivity, improved pharmacokinetic profiles, and minimum toxicities. Pyridine and pyrimidine are presented in natural products and genetic materials. These pyridine/pyrimidine core structures have been noted for their roles in many biological processes as well as in cancer pathogenesis, which make such compounds become attractive scaffolds for discovery of novel drugs. Results & Conclusion: In the recent years, pyridine- and pyrimidine-based anticancer drugs have been developed based on structural modification of these core structures (i.e., substitution with moieties and rings, conjugation with other compounds, and coordination with metal ions). Detailed discussion is provided in this review to highlight the potential of these small molecules as privileged scaffolds with attractive properties and biological activities for the search of novel anticancer agents. © 2017 Bentham Science Publishers.
ISSN: 13895575
Appears in Collections:SCOPUS 1983-2021

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