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Title: Human papillomavirus in anal biopsy tissues and liquid-based cytology samples of HIV-positive and HIV-negative Thai men who have sex with men
Authors: Pankam T.
Kerr S.J.
Teeratakulpisan N.
Rodbamrung P.
Wongkanya R.
Keelawat S.
Ruangritchankul K.
Hongchookiat P.
Watanapokasin R.
Phanuphak N.
Keywords: adult
cohort analysis
controlled study
diagnostic test accuracy study
genotyping technique
Human immunodeficiency virus infection
liquid based cytology
major clinical study
men who have sex with men
papillomavirus infection
prospective study
rectum biopsy
species difference
virus identification
Wart virus
Issue Date: 2017
Abstract: Background Men who have sex with men (MSM) are at high risk of developing human papillomavirus (HPV)-related anal cancer. We compared HPV genotypes in anal tissues (Bx) and anal liquid-based cytology fluid (LBC) from HIV-positive and HIV-negative MSM. Methods Bx (32 normal, 41 low-grade squamous intraepithelial lesions (LSIL) and 22 high-grade squamous intraepithelial lesions (HSIL)), along with LBC from the same visit, were selected from 61 HIV-positive and 34 HIV-negative MSM who enrolled into a prospective cohort in Bangkok, Thailand. HPV genotyping was performed on Bx and LBC. Results Any HPV and high-risk HPV (HR-HPV) prevalence were 63.2% and 60.0% in Bx and 71.6% and 62.1% in LBC, respectively. HIV-positive MSM had higher rates of HR-HPV genotypes detection (70.5% vs. 47.1%, p=0.03) in LBC than HIV-negative MSM. HPV16 (27%) was the most common HR-HPV found in HSIL tissue. In HIV-positive MSM, the frequency of HR-HPV detection increased with histopathologic grading in both Bx and LBC samples. HSIL was associated with the presence of any HR-HPV(OR 7.6 (95%CI 1.8–31.9); P=0.006) in LBC and in Bx((OR 5.6 (95%CI 1.4–22.7); P=0.02). Conclusions Our data strongly support the integration of HR-HPV screening on LBC samples, along with HPV vaccination, into an anal cancer prevention program. © 2017
ISSN: 24058521
Appears in Collections:Scopus 1983-2021

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