Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13051
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dc.contributor.authorThamacharoensuk T.
dc.contributor.authorTaweechotipatr M.
dc.contributor.authorKajikawa A.
dc.contributor.authorOkada S.
dc.contributor.authorTanasupawat S.
dc.date.accessioned2021-04-05T03:22:08Z-
dc.date.available2021-04-05T03:22:08Z-
dc.date.issued2017
dc.identifier.issn15904261
dc.identifier.other2-s2.0-85021825435
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13051-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85021825435&doi=10.1007%2fs13213-017-1280-4&partnerID=40&md5=03ee410a17dc782089e4adf6099a50cc
dc.description.abstractLactic acid bacteria (LAB) are widely known as probiotic microorganisms that afford several health benefits for the host. In this study, 15 isolates of LAB from various sources in Thailand were examined for their probiotic properties. Based on their phenotypic and genetic characteristics, they belong to the genera Lactobacillus, Pediococcus, and Weissella. All isolates showed the ability to induce interleukin-12 (IL-12) at different levels. Cell-free supernatant of Lactobacillus acidipiscis SR7-1 and Lactobacillus farraginis SL4-1 showed an antiproliferative effect against Caco-2 cell lines with non-toxicity to normal cell lines (Vero cells), while they had no effect against U937 cell lines. Five strains, including Lactobacillus namurensis KC78-5, L. farraginis SL4-1, Lactobacillus mucosae SL7-2, Lactobacillus salivarius MSMC120-2 and Pediococcus pentosaceus PC73-3 grew at pH 3. All isolates were tolerant at 1% bile. L. farraginis SL4-1, L. mucosae SL7-2 and P. pentosaceus PC73-3 were not statistically different when compared to the negative control in vitro adhesion assay. These results suggest that L. farraginis SL4-1, L. mucosae SL7-2 and P. pentosaceus PC73-3, which meet the general criteria of probiotics, represent very interesting candidates for further study as anti-cancer agents, especially L. farraginis SL4-1, which has an antiproliferative effect against Caco-2 cells and immunomodulatory ability. These results also highlight the need for further study, especially in appropriate in vivo animal models. © 2017, Springer-Verlag GmbH Germany and the University of Milan.
dc.titleInduction of cellular immunity interleukin-12, antiproliferative effect, and related probiotic properties of lactic acid bacteria isolated in Thailand
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAnnals of Microbiology. Vol 67, No.8 (2017), p.511-518
dc.identifier.doi10.1007/s13213-017-1280-4
Appears in Collections:Scopus 1983-2021

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