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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12994
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dc.contributor.authorWeecharangsan W.
dc.contributor.authorOpanasopit P.
dc.contributor.authorNiyomtham N.
dc.contributor.authorYingyongnarongkul B.-E.
dc.contributor.authorKewsuwan P.
dc.contributor.authorLee R.J.
dc.date.accessioned2021-04-05T03:21:58Z-
dc.date.available2021-04-05T03:21:58Z-
dc.date.issued2017
dc.identifier.issn2507005
dc.identifier.other2-s2.0-85032161426
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12994-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85032161426&doi=10.21873%2fanticanres.12085&partnerID=40&md5=6d730df18e244e989a66841bcef36e08
dc.description.abstractBackground/Aim: This study investigated the codelivery of plasmid DNA and antisense oligodeoxyribonucleotide (AS ODN) into carcinoma cells by cholic acidmodified polyethylenimine (PEI-CA). Materials and Methods: PEI-CA/plasmid DNA and AS ODN complexes were formulated and evaluated for delivery of plasmid DNA and AS ODN in HeLa cells. The efficiency of co-delivery of plasmid DNA and AS ODN was evaluated by cell growth inhibition using p53 and bcl-2 AS ODN. Results: AS ODN intracellular delivery and green fluorescent protein expression upon cellular transfection were greater than in cells treated with uncomplexed nucleic acids. Treatment of the cells with PEI-CA/p53 plasmid DNA and bcl-2 AS ODN complexes resulted in cell growth inhibition that was greater than that of either PEI-CA/p53 plasmid DNA complexes or PEI-CA/bcl-2 AS ODN complexes alone. Conclusion: The co-delivery of p53 plasmid DNA and bcl-2 AS ODN in PEI-CA complexes enhanced therapeutic activities of both p53 plasmid DNA and bcl-2 AS ODN.
dc.subjectantisense oligodeoxynucleotide
dc.subjectcholic acid
dc.subjectgreen fluorescent protein
dc.subjectplasmid DNA
dc.subjectpolyethyleneimine
dc.subjectprotein bcl 2
dc.subjectprotein p53
dc.subjectantisense oligodeoxynucleotide
dc.subjectBCL2 protein, human
dc.subjectprotein bcl 2
dc.subjectprotein p53
dc.subjectagar gel electrophoresis
dc.subjectantineoplastic activity
dc.subjectArticle
dc.subjectcancer inhibition
dc.subjectcarcinoma cell
dc.subjectcell culture
dc.subjectcell growth
dc.subjectcontrolled study
dc.subjectfluorescence activated cell sorting
dc.subjectgenetic transfection
dc.subjectgrowth inhibition
dc.subjecthuman
dc.subjecthuman cell
dc.subjectnonviral gene delivery system
dc.subjectparticle size
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectzeta potential
dc.subjectantagonists and inhibitors
dc.subjectcarcinoma
dc.subjectcell proliferation
dc.subjectdrug effects
dc.subjectdrug potentiation
dc.subjectgene therapy
dc.subjectgene vector
dc.subjectgenetics
dc.subjectHeLa cell line
dc.subjectmetabolism
dc.subjectpharmacology
dc.subjectplasmid
dc.subjectCarcinoma
dc.subjectCell Proliferation
dc.subjectDrug Synergism
dc.subjectGenetic Therapy
dc.subjectGenetic Vectors
dc.subjectGreen Fluorescent Proteins
dc.subjectHeLa Cells
dc.subjectHumans
dc.subjectOligodeoxyribonucleotides, Antisense
dc.subjectPlasmids
dc.subjectProto-Oncogene Proteins c-bcl-2
dc.subjectTumor Suppressor Protein p53
dc.titleSynergistic inhibition of human carcinoma cell growth via co-delivery of p53 plasmid DNA and bcl-2 antisense oligodeoxyribonucleotide by cholic acid-modified polyethylenimine
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAnticancer Research. Vol 37, No.11 (2017), p.6335-6340
dc.identifier.doi10.21873/anticanres.12085
Appears in Collections:Scopus 1983-2021

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