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https://ir.swu.ac.th/jspui/handle/123456789/12493| Title: | Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols |
| Authors: | Soponpong J. Dolsophon K. Thongpanchang C. Linden A. Thongpanchang T. |
| Keywords: | 1,2,3,4 tetrahydro 1,4 epoxynaphthalene 1 carboxylic acid carboxylic acid derivative reagent unclassified drug Article chiral chromatography chirality crystal structure derivatization proton nuclear magnetic resonance reaction analysis synthesis X ray diffraction |
| Issue Date: | 2019 |
| Abstract: | The structure of a constrained bicyclic chiral derivatizing agent (CDA), 1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid, THENA 1, was modified by replacing both exo-methylene protons with deuterium atoms. The modified CDA, THENA-d 2 2, could be used to assign the absolute configuration of chiral secondary alcohols with good reliability. Compared with THENA, the multiplicity of the methylene proton signals in the 1 H NMR spectra of THENA-d 2 derivatives is less complicated and the new CDA thus offers simpler NMR spectra for data interpretation. © 2019 Elsevier Ltd |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/12493 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059805363&doi=10.1016%2fj.tetlet.2019.01.013&partnerID=40&md5=0218c68347ee364cccd5d50634cd65d9 |
| ISSN: | 404039 |
| Appears in Collections: | Scopus 1983-2021 |
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