Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12276
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dc.contributor.authorChinchai T.
dc.contributor.authorPosuwan N.
dc.contributor.authorVuthitanachot V.
dc.contributor.authorWanlapakorn N.
dc.contributor.authorPoovorawan Y.
dc.date.accessioned2021-04-05T03:02:29Z-
dc.date.available2021-04-05T03:02:29Z-
dc.date.issued2019
dc.identifier.issn20721315
dc.identifier.other2-s2.0-85073610428
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12276-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073610428&doi=10.1186%2fs41043-019-0186-0&partnerID=40&md5=8f5da032f0b08d5c5ba9169b425a10ac
dc.description.abstractBACKGROUND: Owing to a declining birth rate and longer lifespan, the number of elderly people (≥ 60 years) in Thailand has grown rapidly. However, the elderly are at significant risk of infectious diseases because they have never been immunized, because they have not been completely immunized, or because their immunity has waned. Immunity against infectious diseases in the elderly is an important means of controlling diseases in the community. Our objective was to evaluate the seroprotective rate against diphtheria, tetanus, and pertussis in the elderly Thai population. METHODS: In total, 430 healthy individuals from the northeastern region of Thailand were enrolled in this study and stratified into five age groups: 60-65, 66-70, 71-75, 76-80, and > 80 years. Serum samples were collected and quantitatively analyzed for diphtheria, tetanus, and pertussis IgG antibody by using commercial ELISA kits. For anti-diphtheria toxoid and anti-tetanus toxoid ELISA, values < 0.01 IU/ml were interpreted as seronegative, and for anti-Bordetella pertussis toxin ELISA, values < 5 IU/ml were interpreted as seronegative; these definitions were in accord with previous studies. RESULTS: For diphtheria toxoid Ab, the majority of the population had antibody levels > 0.01 IU/ml. For tetanus anti-toxoid Ab, the majority of the population had antibody levels of > 0.01 IU/ml, of which approximately 34% had durable antibody protection levels (DAPL) of ≥ 1 IU/ml. Meanwhile, nearly 45% of the population had an Ab level against pertussis lower than the protectivity level. CONCLUSIONS: In total, 97.2%, 83.5%, and 55.8% of the population had a higher antibody level than the minimal protective level for diphtheria, tetanus, and pertussis, respectively. In order to prevent an outbreak of these diseases in the future, the elderly should be administered with Tdap revaccination to provide diphtheria herd immunity in the population; this will increase cocoon phenomenon for pertussis and protect the population from tetanus-prone injury.
dc.subjectbacterium antibody
dc.subjectaged
dc.subjectblood
dc.subjectdiphtheria
dc.subjectenzyme linked immunosorbent assay
dc.subjectepidemiology
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectmale
dc.subjectpertussis
dc.subjectsecondary immunization
dc.subjectseroepidemiology
dc.subjecttetanus
dc.subjectThailand
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAntibodies, Bacterial
dc.subjectDiphtheria
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunization, Secondary
dc.subjectMale
dc.subjectSeroepidemiologic Studies
dc.subjectTetanus
dc.subjectThailand
dc.subjectWhooping Cough
dc.titleSeroprevalence of an antibody against diphtheria, tetanus, and pertussis among the elderly in Khon Kaen, Thailand
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of health, population, and nutrition. Vol 38, No.1 (2019), p.28
dc.identifier.doi10.1186/s41043-019-0186-0
Appears in Collections:Scopus 1983-2021

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