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Title: Event-free survival at 12 months is a strong surrogate endpoint for stage 1 diffuse large B cell lymphoma: a report from Nation Wide Registry Thai Lymphoma Study Group
Authors: Wudhikarn K.
Bunworasate U.
Julamanee J.
Lekhakula A.
Ekwattanakit S.
Khuhapinant A.
Niparuck P.
Chuncharunee S.
Numbenjapon T.
Prayongratana K.
Kanitsap N.
Wongkhantee S.
Makruasi N.
Wong P.
Norasetthada L.
Nawarawong W.
Sirijerachai C.
Chansung K.
Suwanban T.
Praditsuktavorn P.
Intragumtornchai T.
on behalf of Thai Lymphoma Study Group
Keywords: adult
advanced cancer
cancer patient
cancer prognosis
cancer radiotherapy
cancer staging
cancer survival
controlled study
diffuse large B cell lymphoma
event free survival
human tissue
intensive care
major clinical study
multivariate analysis
outcome assessment
overall survival
predictive value
priority journal
prospective study
systemic therapy
treatment response
Issue Date: 2020
Abstract: Event-free survival at 12 months (EFS12) is a surrogate endpoint for long-term outcomes in many histologic lymphoma subtypes. However, most reports have primarily investigated the implication of EFS12 in advanced-stage non-Hodgkin lymphoma (NHL). There are limited data regarding the significance of EFS12 in early-stage NHL. Herein, we evaluated the prognostic significance of EFS12 in patients with stage 1 diffuse large B-cell lymphoma (DLBCL). Out of 282 patients with stage 1 DLBCL who received intensive therapy, 227 (80.5%) achieved EFS12. The 4-year overall survival (OS) was 91.4% and 4.0% for patients who achieved and failed to achieve EFS12, respectively. Multivariable analyses demonstrated response to treatment and achievement of EFS12 as independent predictors for OS. In conclusion, our study demonstrated EFS12 as a powerful prognostic factor for stage 1 DLBCL. Further validation in more extensive prospective studies is warranted. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
ISSN: 10428194
Appears in Collections:SCOPUS 1983-2021

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