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Title: Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response
Authors: Srikiatkhachorn A.
Anuntasethakul T.
Phansuwan-Pujito P.
Patumraj S.
Kasantikul V.
Keywords: glyceryl trinitrate
nitric oxide
protein fos
animal experiment
animal model
animal tissue
blood vessel reactivity
brain circulation
controlled study
nociceptive stimulation
oxidative stress
pia mater
priority journal
serotonin release
trigeminal nucleus
Issue Date: 2001
Abstract: The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunoreactivity trigeminal nucleus caudalis neurons was used as an indicator for the cerebrovascular nociception. The results showed that the degree of nitric oxide-induced pial microvascular dilatation was significantly greater in the seroton-indepleted group than the control. The number of nitric oxide-evoked Fos-immunoreactive cells between the two groups remained comparable. The results suggest that though depletion of serotonin can facilitate the vascular response to nitric oxide it does not alter the nitric oxide-induced craniovascular nociceptive response. © 2001 Lippincott Williams & Wilkins.
ISSN: 9594965
Appears in Collections:Scopus 1983-2021

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