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|Title:||A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity|
|Keywords:||1,2,3,6 tetrahydro 4 phenylpyridine|
n acetyl 2(1 adamantylsulfoxo) 3 acetoxy 4 phenyl 6 hydroxy 1,2,3,6 tetrahydropyridine
minimum inhibitory concentration
nuclear magnetic resonance
thin layer chromatography
|Abstract:||Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.|
|Appears in Collections:||Scopus 1983-2021|
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