Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAsawaworarit P.
dc.contributor.authorChuanchaiyakul S.
dc.contributor.authorKamanamool N.
dc.contributor.authorPiyavechvirat T.
dc.contributor.authorUdompataikul M.
dc.description.abstractBackground: Striae are commonly developed in adolescence as a result of active growth spurt. Although they create little physical health issue, they are cosmetic concerns to the patients. Effective striae treatment can help improve their mental health and personality. Objective: To compare the effects of a herbal extract cream and 0.1% tretinoin cream in the treatment of striae alba. Material and Method: Forty eight participants aged between 10 - 19 years old, with striae alba at their thighs were rand­omized into two groups. Each group was separately treated with 0.1% tretinoin and herbal extract for 16 weeks. The width, length and surface roughness of the lesions were assessed including histological evaluation and participants’ satisfaction. Results: Thirty nine participants completed the study after 16 weeks. Compared to initial lesions, the striae width was reduced by 9.01% (p = 0.002) in tretinoin group and 13.09% (p<0.001) in herbal extract group. The length was reduced by 9.54% in tretinoin group (p<0.001) and 8.73% in herbal extract group (p<0.001). The surface roughness assessed by Visioscan VC98 was reduced by 13.70% in tretinoin group (p = 0.036) and 17.24% in herbal extract group (p<0.001). From H&E staining, the mean difference of epidermal thickness was 4.79±7.15 microns in tretinoin group and 14.22±16.98 microns in herbal extract group. The mean difference of collagen amount was 13.75±6.02 units in tretinoin group and 6.60±4.92 units in herbal extract group. From Masson trichrome staining, the mean difference of collagen amount was 6.75±3.50 units in tretinoin group and 12.20±7.73 units in herbal extract group. From Verhoff van Gieson staining, the mean difference of elastin amount was 2.25±3.30 units in tretinoin group and 5.40±4.16 units in herbal extract group. There was no statistical significant difference between two groups in histological evaluation. The herbal extract caused irritant contact dermatitis only 4.55% in contrast to 72.73% from the tretinoin group. Most participants from both groups had moderate to high satisfactionaccording to the efficacy of their treatments. Conclusion: The herbal extract cream is as effective as 0.1% tretinoin cream in the treatment of striae alba. As tretinoin can cause skin irritation, the herbal extract can be a better alternative treatment. © 2017, Medical Association of Thailand. All rights reserved.
dc.subjectherbaceous agent
dc.subjectpalmitoyl tripeptide
dc.subjectretinoic acid
dc.subjectsqualene oil
dc.subjectunclassified drug
dc.subjectAloe vera
dc.subjectCentella asiatica
dc.subjectclinical article
dc.subjectclinical evaluation
dc.subjectcollagen synthesis
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjecthuman tissue
dc.subjectirritant dermatitis
dc.subjectpatient satisfaction
dc.subjectrandomized controlled trial
dc.subjectsample size
dc.subjectschool child
dc.subjectskin defect
dc.subjectskin irritation
dc.subjectskin redness
dc.subjectskinfold thickness
dc.subjectultraviolet A radiation
dc.subjectyoung adult
dc.titleThe comparative study of topical therapy on striae alba between a herbal extract cream and 0.1% tretinoin cream in adolescence
dc.identifier.bibliograpycitationJournal of the Medical Association of Thailand. Vol 100, No.1 (2017), p.93-99
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.

Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.