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Title: Associations of left ventricular systolic dysfunction with the factors among Thai patients on peritoneal dialysis: A cross-sectional study
Authors: Angkananard T.
Janma J.
Wannasiri T.
Sangthong P.
Changsirikulchai S.
Keywords: phosphate
coronary artery disease
correlational study
cross-sectional study
diabetes mellitus
disease association
heart left ventricle ejection fraction
human cell
laboratory test
left ventricular systolic dysfunction
major clinical study
medical history
middle aged
neutrophil lymphocyte ratio
peritoneal dialysis
phosphate blood level
sex ratio
Thai (people)
university hospital
chronic kidney failure
heart left ventricle function
risk factor
Cross-Sectional Studies
Kidney Failure, Chronic
Middle Aged
Peritoneal Dialysis
Risk Factors
Ventricular Dysfunction, Left
Issue Date: 2019
Abstract: Background: Factors associated with left ventricular systolic dysfunction (LVSD) of peritoneal dialysis (PD) patients are limited. We aim to explore and quantify the associated factors of LVSD among PD patients. Methods: Participants from a PD clinic treated between 2012 and 2014 at the HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakhon Nayok, Thailand were recruited and divided into 2 groups according to their left ventricular ejection fraction (LVEF) (< 50% vs. ≥ 50%) with LVEF < 50% considered as LVSD. Correlations among the clinical, laboratory and echocardiographic variables were analyzed. The factors associated with LVSD were explored with univariate and multivariate logistic regression analyses. Beta coefficient along with odds ratio and 95% confidence interval (CI) were calculated and the P value < 0.05 was considered significant. Results: Among 103 subjects stratified as LVSD (n = 18, 17.5%). The mean (SD) age was 59.3 (12.7) years, and nearly halves were males. Preexisting CAD, diabetes (DM) and current smoking were 20 (19.4%), 63 (61.2%) and 23 (22.3%) patients, respectively. The median time of dialysis vintage was 12 (3, 24) months. Factors associated with LVSD and corresponding ORs with 95% CI by multivariate analysis were prior coronary artery disease (CAD) [5.08 (1.16, 22.19)], DM [6.36 (1.29, 31.49)], smoking [10.62 (2.17, 51.99)], neutrophil to lymphocyte ratio (NLR) > 3.6 [6.77 (1.41, 32.52)], and high serum phosphate [9.39 (2.16, 40.92)] were significantly associated with LVSD. Conclusions: Prior history of CAD, DM, smoking, high NLR and serum phosphate levels were found to be associated with LVSD for our PD patients. The evidence from prospective study is needed to confirm the predictive value of these variables. © 2019 The Author(s).
ISSN: 14712369
Appears in Collections:Scopus 1983-2021

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