Abstract:
Background: Intranasal corticosteroid (INCS) is one of the most effective treatments for
allergic rhinitis (AR). To achieve optimum efficiency while avoiding adverse effects (AEs),
patients must comply with and follow the drug administration instructions.
Objective: To evaluate INCS administration techniques and steps and the association
between inaccurate drug administration and AEs.
Methods: A descriptive cross-sectional study was performed in patients diagnosed with AR
who had used an INCS for more than 1 month at the HRH Princess Maha Chakri Sirindhorn
Medical Center, Nakhon Nayok, Thailand between September 2020 and August 2021. Patient
information was collected, evaluate the accuracy of the application techniques and the steps
they followed for INCS administration and the occurrence of any associated AEs.
Results: In total, 150 subjects diagnosed with AR met the criteria. Only 6 patients (4%) correctly
performed all 12 steps of INCS administration, while 44 patients (29.33%) correctly performed
the 5 recommended essential steps. AEs were found in 23 patients (15.33%), with not pointing
the tip slightly outward away from the septum significantly associated with a 3.6 times higher
risk of AEs in patients (odds ratio, 3.6; 95% confidence interval, 1.3–9.4; p = 0.012).
Conclusion: Investigations into INCS use in patients with AR revealed that only 4% of
patients correctly performed all the administration techniques and steps, while 30% of
patients at least followed the 5 recommended essential steps perfectly. Not pointing the tip
slightly outward away from the septum was found to result in the most AEs.
