Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29555
ชื่อเรื่อง: A comparison of the efficacy and safety profiles of 10% salicylic acid and 10% urea creams in treating acanthosis nigricans in adolescents: a randomized double-blinded study
ผู้แต่ง: Treesirichod A.
Thaneerat N.
Kangvanskol W.
Keywords: Acanthosis nigricans
Adolescent
Hyperpigmentation
Salicylic acid
Treatment
Urea
วันที่เผยแพร่: 2023
สำนักพิมพ์: Institute for Ionics
บทคัดย่อ: Acanthosis nigricans is characterized by the presence of velvety hyperpigmentation of the skin over the neck and the flexural areas. Regardless of different modalities of treatment, none provides a definite standard cure. This study aims to assess the efficacy of topical 10% salicylic acid compared to 10% urea cream in treating acanthosis nigricans in adolescents. A randomized comparative, double-blind study is conducted on adolescents with acanthosis nigricans of the posterior neck. Treatment efficacy was assessed via a narrowband reflectance spectrophotometer at individual follow-up visits at weeks 2, 4, and 8, while the overall success rates were evaluated by the investigator-assessed and participant-assessed global evaluation scales (IGE and PGE). Acanthosis nigricans scoring chart (ANSC) and adverse effects are also assessed. A total of 39 participants with acanthosis nigricans enrolled and completed the study. Throughout the 8-week period of treatment, the use of 10% salicylic acid demonstrated strong effectiveness in treatment with 14.6 ± 10.6% improvement, while the 10% urea demonstrated 12.5 ± 10.9% improvement. Findings from the overall global evaluation scales were consistent with the results from the narrowband reflectance spectrophotometer. Treatment with 10% salicylic and 10% urea produced no serious local skin adverse reactions. Both medications improve neck hyperpigmentation associated with acanthosis nigricans in adolescents, in which the 10% salicylic acid and 10% urea cream demonstrate similar efficacy and safety profiles. Clinical Trials Registry: TCTR20201123003. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150517660&doi=10.1007%2fs00403-023-02605-6&partnerID=40&md5=cd1e1eaacd3986a22437c3e7d1735e95
https://ir.swu.ac.th/jspui/handle/123456789/29555
Appears in Collections:Scopus 2023

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