Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29485
Full metadata record
DC FieldValueLanguage
dc.contributor.authorUttayarat P.
dc.contributor.authorChiangnoon R.
dc.contributor.authorThongnopkoon T.
dc.contributor.authorNoiruksa K.
dc.contributor.authorTrakanrungsie J.
dc.contributor.authorPhattanaphakdee W.
dc.contributor.authorChittasupho C.
dc.contributor.authorAthikomkulchai S.
dc.contributor.otherSrinakharinwirot University
dc.date.accessioned2023-11-15T02:08:43Z-
dc.date.available2023-11-15T02:08:43Z-
dc.date.issued2023
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85146777515&doi=10.3390%2fgels9010052&partnerID=40&md5=780e6fb7049f6bb8707ac81631a98103
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/29485-
dc.description.abstractThe use of bioactive molecules derived from medicinal plants in wound healing has recently attracted considerable attention in both research and public interest. In this work, we demonstrated the first attempt to incorporate the extract from Thai red onion skins in hydrogel patches intended for transdermal delivery. The red onion skin extract (ROSE) was first prepared and evaluated for cytotoxicity by MTT assay with both L929 and human dermal fibroblast cells. Hydrogel patches with porous microstructure and high water content were fabricated from polyvinyl alcohol (PVA) by electron beam irradiation and characterized for their physical, mechanical, morphological, and cytocompatible properties prior to the loading of ROSE. After decontamination by electron beam irradiation, the in vitro release profile exhibited the burst release of extract from ROSE-coated hydrogel patches within 5 h, followed by the sustained release up to 48 h. Finally, evaluation of skin permeation using Franz cell setup with a newborn pig skin model showed that the permeation of ROSE from the hydrogel patch increased with time and reached the maximum of 262 µg/cm2, which was well below the cytotoxicity threshold, at 24 h. These results demonstrated that our ROSE-coated hydrogel patches could potentially be used in transdermal delivery. © 2023 by the authors.
dc.publisherMDPI
dc.subjectAllium cepa
dc.subjectelectron beam irradiation
dc.subjecthydrogel
dc.subjecttransdermal delivery
dc.subjectwound healing
dc.titleElectron Beam Irradiation Cross-Linked Hydrogel Patches Loaded with Red Onion Peel Extract for Transdermal Drug Delivery: Formulation, Characterization, Cytocompatibility, and Skin Permeation
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationGels. Vol 9, No.1 (2023)
dc.identifier.doi10.3390/gels9010052
Appears in Collections:Scopus 2023

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.