Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29423
ชื่อเรื่อง: Familial clustering of nonalcoholic fatty liver disease in first-degree relatives of adults with lean nonalcoholic fatty liver disease
ผู้แต่ง: Niltwat S.
Limwongse C.
Charatcharoenwitthaya N.
Bunditvorapoom D.
Bandidniyamanon W.
Charatcharoenwitthaya P.
Keywords: first-degree relatives
heritability
lean
nonalcoholic fatty liver disease
PNPLA3
วันที่เผยแพร่: 2023
สำนักพิมพ์: John Wiley and Sons Inc
บทคัดย่อ: Background and Aims: The heritability of nonalcoholic fatty liver disease (NAFLD) in lean individuals is undetermined. This familial aggregation study aimed to evaluate familial linkage for NAFLD and the risk of NAFLD among first-degree relatives of probands with lean NAFLD. Methods: This study prospectively recruited cohorts of probands with lean NAFLD, probands with obese NAFLD, and lean probands with non-NAFLD and their respective first-degree relatives. A total of 257 participants were evaluated for liver steatosis, defined by the controlled attenuation parameter ≥288 dB/m2, metabolic characteristics, and the PNPLA3, TM6SF2, and MBOAT7 polymorphisms. Results: The prevalence of NAFLD in first-degree relatives of lean NAFLD probands (39.9%) was similar to that in the obese NAFLD group (36.9%) and was significantly higher than in lean persons without NAFLD (19.1%). First-degree relatives of probands with NAFLD who were male, and had central obesity, hypertriglyceridaemia, insulin resistance, and the PNPLA3 rs738409C>G allele had a significantly higher prevalence of NAFLD. After multivariable adjustment for gender, metabolic characteristics, and the PNPLA3 rs738409C>G allele, first-degree relatives of probands with lean NAFLD (odds ratio [OR], 5.13; 95% CI, 1.77–14.86) and obese NAFLD (OR, 3.20; 95% CI, 1.14–8.99) exhibited an increased risk of NAFLD compared with those of lean controls without NAFLD. Conclusions: Our well-phenotype cohorts revealed familial clustering of NAFLD and higher risks of NAFLD in first-degree relatives of probands with lean or obese NAFLD. The findings encourage clinicians caring for NAFLD patients to be more vigilant for NAFLD in their family members. © 2023 The Authors. Liver International published by John Wiley & Sons Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85173440436&doi=10.1111%2fliv.15758&partnerID=40&md5=6552ea0b1d4a6823b09baac3419da1cd
https://ir.swu.ac.th/jspui/handle/123456789/29423
Appears in Collections:Scopus 2023

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