Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29419
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dc.contributor.authorTran A.T.L.
dc.contributor.authorSukajintanakarn C.
dc.contributor.authorSenawongse P.
dc.contributor.authorSritanaudomchai H.
dc.contributor.authorRuangsawasdi N.
dc.contributor.authorLapthanasupkul P.
dc.contributor.authorKitkumthorn N.
dc.contributor.authorMonmaturapoj N.
dc.contributor.authorKhamsut C.
dc.contributor.authorNaruphontjirakul P.
dc.contributor.authorPongprueksa P.
dc.contributor.otherSrinakharinwirot University
dc.date.accessioned2023-11-15T02:08:36Z-
dc.date.available2023-11-15T02:08:36Z-
dc.date.issued2023
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85162780863&doi=10.1055%2fs-0042-1758789&partnerID=40&md5=a3f9e8cf0f3306666b7884ca517a42c4
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/29419-
dc.description.abstractObjective To evaluate the potential of modified bioactive glasses containing lithium and zinc as pulp capping materials by investigating the odontogenic differentiation and mineralization response in the tooth culture model. Materials and Methods Lithium- and zinc-containing bioactive glasses (45S5.1Li, 45S5.5Li, 45S5.1Zn, 45S5.5Zn, 45S5.1Zn sol-gel, and 45S5.5Zn sol-gel), fibrinogen-thrombin, and biodentine were prepared to assess Axin2 gene expression at 0, 30 minutes, 1 hour, 12 hours, and 1 day and DSPP gene expression at 0, 3, 7, and 14 days in stem cells from human exfoliated deciduous teeth (SHEDs) using qRT-PCR. The experimental bioactive glasses incorporated with fibrinogen-thrombin and biodentine were placed on the pulpal tissue in the tooth culture model. Histology and immunohistochemistry were analyzed at 2 weeks and 4 weeks. Results Axin2 gene expression for all experimental groups was significantly higher than the control at 12 hours. The DSPP gene expression for all experimental groups was significantly higher than the control at 14 days. The presence of mineralization foci was significantly higher at 4 weeks for the modified bioactive glasses 45S5.5Zn, 45S5.1Zn sol-gel, and 45S5.5Zn sol-gel as well as Biodentine compared with the fibrinogen-thrombin control. Conclusion Lithium - and zinc - containing bioactive glasses increased Axin2 and DSPP gene expression in SHEDs and can potentially enhance pulp mineralization and regeneration. Zinc - containing bioactive glasses are a promising candidate to be used as pulp capping materials. © 2023 Georg Thieme Verlag. All rights reserved.
dc.publisherGeorg Thieme Verlag
dc.subjectbioactive glass
dc.subjectfibrinogen thrombin
dc.subjectlithium bioactive glass
dc.subjecttooth culture model
dc.subjectzinc bioactive glass
dc.titleInfluence of Lithium- and Zinc-Containing Bioactive Glasses on Pulpal Regeneration
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationEuropean Journal of Dentistry. Vol , No. (2023)
dc.identifier.doi10.1055/s-0042-1758789
Appears in Collections:Scopus 2023

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