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DC Field | Value | Language |
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dc.contributor.author | Kaewnok N. | |
dc.contributor.author | Chailek N. | |
dc.contributor.author | Muansrichai W. | |
dc.contributor.author | Wangngae S. | |
dc.contributor.author | Petdum A. | |
dc.contributor.author | Panchan W. | |
dc.contributor.author | Kamkaew A. | |
dc.contributor.author | Sirirak J. | |
dc.contributor.author | Swanglap P. | |
dc.contributor.author | Sooksimuang T. | |
dc.contributor.author | Wanichacheva N. | |
dc.contributor.other | Srinakharinwirot University | |
dc.date.accessioned | 2023-11-15T02:08:12Z | - |
dc.date.available | 2023-11-15T02:08:12Z | - |
dc.date.issued | 2023 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164299191&doi=10.1016%2fj.jphotochem.2023.114968&partnerID=40&md5=9ae42a3b063b691440460a17bb5bd821 | |
dc.identifier.uri | https://ir.swu.ac.th/jspui/handle/123456789/29241 | - |
dc.description.abstract | Mercury pollution and its toxicity pose a grave threat to health. Therefore, developing new approaches for detecting mercury ions (Hg2+) in environmental and biological samples is crucial. Herein, a novel [5]helicene-based fluorescence sensor (M201NHP) was designed and synthesized for rapid, sensitive and specific detection of Hg2+. The sensor exhibits fluorescence quenching with a very large Stokes shift (192 nm) towards Hg2+ in aqueous acetonitrile media. The detection limit of the sensor is estimated to be 1.94 ppb, which is lower than the U.S. EPA specification for the maximum Hg2+ level in drinking water. Moreover, M201NHP offers five cycles of reversibility upon competitive chelation of cysteine. The sensor can also screen for Hg2+ contamination in real water samples and skincare products. Additionally, it can track Hg2+ in potential mercury-accumulated human cell lines derived from brain tumours, embryonic kidneys, skin and liver cancers with low cytotoxicity. These results indicate that M201NHP is a promising Hg2+ sensor that can prevent health risks and environmental impacts caused by mercury pollution. © 2023 Elsevier B.V. | |
dc.publisher | Elsevier B.V. | |
dc.subject | Cell imaging | |
dc.subject | Fluorescence sensor | |
dc.subject | Hg<sup>2+</sup> sensor | |
dc.subject | Rapid detection | |
dc.subject | [5]Helicene | |
dc.title | Novel [5]helicene derivative as reversible and selective Hg2+ fluorescence sensor and its application in human cells | |
dc.type | Article | |
dc.rights.holder | Scopus | |
dc.identifier.bibliograpycitation | Journal of Photochemistry and Photobiology A: Chemistry. Vol 444, No. (2023) | |
dc.identifier.doi | 10.1016/j.jphotochem.2023.114968 | |
Appears in Collections: | Scopus 2023 |
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