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https://ir.swu.ac.th/jspui/handle/123456789/29241
ชื่อเรื่อง: | Novel [5]helicene derivative as reversible and selective Hg2+ fluorescence sensor and its application in human cells |
ผู้แต่ง: | Kaewnok N. Chailek N. Muansrichai W. Wangngae S. Petdum A. Panchan W. Kamkaew A. Sirirak J. Swanglap P. Sooksimuang T. Wanichacheva N. |
Keywords: | Cell imaging Fluorescence sensor Hg<sup>2+</sup> sensor Rapid detection [5]Helicene |
วันที่เผยแพร่: | 2023 |
สำนักพิมพ์: | Elsevier B.V. |
บทคัดย่อ: | Mercury pollution and its toxicity pose a grave threat to health. Therefore, developing new approaches for detecting mercury ions (Hg2+) in environmental and biological samples is crucial. Herein, a novel [5]helicene-based fluorescence sensor (M201NHP) was designed and synthesized for rapid, sensitive and specific detection of Hg2+. The sensor exhibits fluorescence quenching with a very large Stokes shift (192 nm) towards Hg2+ in aqueous acetonitrile media. The detection limit of the sensor is estimated to be 1.94 ppb, which is lower than the U.S. EPA specification for the maximum Hg2+ level in drinking water. Moreover, M201NHP offers five cycles of reversibility upon competitive chelation of cysteine. The sensor can also screen for Hg2+ contamination in real water samples and skincare products. Additionally, it can track Hg2+ in potential mercury-accumulated human cell lines derived from brain tumours, embryonic kidneys, skin and liver cancers with low cytotoxicity. These results indicate that M201NHP is a promising Hg2+ sensor that can prevent health risks and environmental impacts caused by mercury pollution. © 2023 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164299191&doi=10.1016%2fj.jphotochem.2023.114968&partnerID=40&md5=9ae42a3b063b691440460a17bb5bd821 https://ir.swu.ac.th/jspui/handle/123456789/29241 |
Appears in Collections: | Scopus 2023 |
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