Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29221
ชื่อเรื่อง: Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial
ผู้แต่ง: Lam-Ubol A.
Sukhaboon J.
Rasio W.
Tupwongse P.
Tangshewinsirikul T.
Trachootham D.
Keywords: clinical trial
Nutri-Jelly
oral cancer
p53
PEITC
quality of life
survival
tertiary chemoprevention
วันที่เผยแพร่: 2023
สำนักพิมพ์: Multidisciplinary Digital Publishing Institute (MDPI)
บทคัดย่อ: TP53 mutation is associated with cancer progression. Novel strategies to reboot p53 are required to stabilize the disease and improve survival. This randomized placebo-controlled trial investigated safety and efficacy of Nutri-PEITC Jelly (a texture-modified nutritious diet fortified with β-phenethyl isothiocyanate (PEITC) on oral cancer. Seventy-two patients with advanced-staged oral or oropharyngeal cancer were randomly assigned to study and control groups, who consumed 200 g of Nutri-Jelly with and without 20 mg of PEITC, respectively, 5 days/week for 12 weeks. Outcomes, including adverse events, health-related quality of life (HRQOL), progression-free survival (PFS), tumor response, serum p53, and cytochrome c, were measured at 0, 1, and 3 months. Results show that the study group had a higher proportion of participants with improved HRQOL, stable disease, and increased serum p53 levels than those in the control group (p < 0.001). The PFS time in the study group was significantly longer than that of the control group (p < 0.05). Serum cytochrome c levels were non-significantly decreased in the study group. No serious intervention-related adverse events occurred in either group. In conclusion, Nutri-PEITC Jelly intake for 3 months is safe, stabilizes the disease, improves quality of life and progression-free survival, and might re-activate p53 in advanced-stage oral and oropharyngeal cancer patients. © 2023 by the authors.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159276189&doi=10.3390%2fijms24097824&partnerID=40&md5=02e1d204e7f7829670e55767bb6382f6
https://ir.swu.ac.th/jspui/handle/123456789/29221
Appears in Collections:Scopus 2023

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