Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29160
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dc.contributor.authorKhuancharee K.
dc.contributor.authorTanunyutthawongse C.
dc.contributor.authorSuwanchatchai C.
dc.contributor.authorWannaiampikul S.
dc.contributor.otherSrinakharinwirot University
dc.date.accessioned2023-11-15T02:08:02Z-
dc.date.available2023-11-15T02:08:02Z-
dc.date.issued2023
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85152293224&doi=10.31584%2fjhsmr.2023923&partnerID=40&md5=c6888ecb84042a780a3d336716124048
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/29160-
dc.description.abstractObjective: This study aimed to investigate whether the risk of gout was associated with the ABCG2 rs2231142 variant and how this was affected by metabolic parameters. Material and Methods: The subjects were selected from the genetic variations of urate transporter genes in hyperuricemia and gout in the Thai population (GUHGTH) study. Overall, 96 participants aged 30-60 years were included in the study. Adjusted odds ratio (AORs) of gout was analyzed using multiple logistic regression models and the effects of combinations of ABCG2 rs2231142 variants and metabolic parameters on gout were explored. Results: The TG and TT genotypes of ABCG2 rs2231142 and hyperglycemia were significantly associated with gout risk. The risk of gout was significantly increased by the combined association of ABCG2 rs2231142 and metabolic parameters obesity and hyperglycemia for the TG and TT genotypes compared to the GG genotype (wild-type genotype). Conclusion: In conclusion, the ABCG2 rs2231142 variant was found to be a genetic risk factor for gout in Thai men. Obesity and hyperglycemia combined with the ABCG2 rs2231142 risk allele contributed to an increase in the risk of gout. Further case-control studies with larger sample sizes should be performed to confirm the combinations of the ABCG2 rs2231142 variant, obesity, and hyperglycemia on the risk of gout. © 2023 JHSMR. Hosted by Prince of Songkla University. All rights reserved.
dc.publisherPrince of Songkla University
dc.subjectABCG2 rs2231142 variant
dc.subjectcombinations
dc.subjectgout
dc.subjectmen
dc.subjectmetabolic parameters
dc.titleAssociations and Combinations of Metabolic Parameters and ABCG2 rs2231142 Variant in Thai Men with Gout
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Health Science and Medical Research. Vol 41, No.3 (2023)
dc.identifier.doi10.31584/jhsmr.2023923
Appears in Collections:Scopus 2023

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