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ชื่อเรื่อง: | Efficacy of moisturizers in paediatric atopic dermatitis: A systematic review and meta-analysis of randomised controlled trials |
ผู้แต่ง: | Kritsanaviparkporn C. Sangaphunchai P. Treesirichod A. |
Keywords: | antihistaminic agent calcineurin corticosteroid pimecrolimus atopic dermatitis data analysis disease exacerbation disease severity drug efficacy eczema erythema |
วันที่เผยแพร่: | 2022 |
บทคัดย่อ: | Background: Topical moisturizer is recommended for atopic dermatitis. Aims: The aim of the study was to investigate the knowledge gap regarding the efficacy of moisturizer in young patients. Methods: A systematic review and meta-analysis were conducted on randomised controlled trials comparing participant’s ≤15 years with atopic dermatitis, receiving either topical moisturizer or no moisturizer treatment. Certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. Results: Six trials were included (intervention n= 436; control n= 312). Moisturizer use extended time to flare by 13.52 days (95% confidence interval 0.05–26.99, I2 88%). Greater reduction in risk of relapse was observed during the first month of latency (pooled risk ratio 0.47, 95% confidence interval 0.31–0.72, I2 28%) compared to the second and third months (pooled risk ratio 0.65, 95% confidence interval 0.47–0.91, I2 35% and pooled risk ratio 0.63, 95% confidence interval 0.47–0.83, I2 33%, respectively).Treated patients were 2.68 times more likely to experience a three–six months remission (95% confidence interval1.18–6.09, I2 56%). Moisturizer minimally improved disease severity and quality of life. Limitations: There is a dire need to conduct randomised controlled trials with more robust and standardised designs. Conclusion: Moisturizer benefits young patients with atopic dermatitis. However, more research is needed to better estimate its efficacy. © 2022 Indian Journal of Dermatology, Venereology and Leprology - Published by Scientific Scholar |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123124205&doi=10.25259%2fIJDVL_1384_20&partnerID=40&md5=e989027d7191091d680ace8251495180 https://ir.swu.ac.th/jspui/handle/123456789/27504 |
ISSN: | 3786323 |
Appears in Collections: | Scopus 2022 |
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