Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27437
ชื่อเรื่อง: The use of high resolution optical coherence tomography (HR-OCT) in the diagnosis of ocular surface masqueraders
ผู้แต่ง: Theotoka D.
Wall S.
Galor A.
Sripawadkul W.
Khzam R.A.
Tang V.
Sander D.L.
Karp C.L.
Keywords: Amyloid
Classic
Epithelial
HR-OCT
Lymphoma
Masquerade
Melanoma
Ocular surface
Ocular surface squamous neoplasia
Squamous cell carcinoma
Subepithelial
วันที่เผยแพร่: 2022
สำนักพิมพ์: Elsevier Inc.
บทคัดย่อ: Introduction: Ocular surface masqueraders encompass any ocular surface lesion masquerading as another ocular surface lesion. High resolution optical coherence tomography (HR-OCT) has emerged as an adjunctive tool to clinical acumen. This study's purpose is to evaluate the utility of HR-OCT images in guiding the diagnosis and management of those lesions. Material and methods: 22 individuals with a clinically ambiguous ocular surface lesion with slit lamp photographs (SLP), HR-OCT images, and histopathological examination were included in the study. The presumptive clinical diagnosis based on SLP was compared to the diagnosis suggested by HR-OCT findings and to definitive diagnosis by histopathology. The main outcome of this study was the frequency in which HR-OCT findings guided the clinician to the correct diagnosis. Results: 7 lesions were epithelial, 3 had an epithelial and a subepithelial component, and 12 were subepithelial. HR-OCT was most effective in discerning lesion location, successfully identifying the location in 100% of cases. Classic HR-OCT findings were detected in 68.2% of cases while suggestive features were detected in 31.8% of cases. The epithelial lesions' mean epithelial thickness was 265.4 ± 140.6 μm, the subepithelial lesions' mean was 58.0 ± 25.0 μm, and the combined lesions’ mean was 140.0 ± 70.0 μm. The epithelium was significantly thicker in epithelial lesions compared to subepithelial and combined lesions. By ROC analysis we identified that using a cut off of 156 μm, the sensitivity was 86% and the specificity was 93%. Discussion: HR-OCT can be a valuable diagnostic tool, assisting in the differentiation of ambiguous ocular surface pathologies by providing a cross-sectional, morphological image of the lesion. © 2022 Elsevier Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125717212&doi=10.1016%2fj.jtos.2022.02.003&partnerID=40&md5=325f4355e398b46d5db3fbf6793c089d
https://ir.swu.ac.th/jspui/handle/123456789/27437
ISSN: 15420124
Appears in Collections:Scopus 2022

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