Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27398
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dc.contributor.authorChanhom N.
dc.contributor.authorJittikoon J.
dc.contributor.authorWattanapokayakit S.
dc.contributor.authorMahasirimongkol S.
dc.contributor.authorCharoenyingwattana A.
dc.contributor.authorUdomsinprasert W.
dc.contributor.authorChaikledkaew U.
dc.contributor.authorSuvichapanich S.
dc.contributor.authorMushiroda T.
dc.contributor.authorKiertiburanakul S.
dc.contributor.authorRojanawiwat A.
dc.contributor.authorWangsomboonsiri W.
dc.contributor.authorManosuthi W.
dc.contributor.authorKantipong P.
dc.contributor.authorApisarnthanarak A.
dc.contributor.authorSangsirinakakul W.
dc.contributor.authorWongprasit P.
dc.contributor.authorChaiwarith R.
dc.contributor.authorTantisiriwat W.
dc.contributor.authorSungkanuparph S.
dc.contributor.authorChantratita W.
dc.date.accessioned2022-12-14T03:17:17Z-
dc.date.available2022-12-14T03:17:17Z-
dc.date.issued2022
dc.identifier.issn20754426
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85132189001&doi=10.3390%2fjpm12060940&partnerID=40&md5=da381111ea8ea46dc0d63c7c1553c66d
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/27398-
dc.description.abstractGlutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of GSTs can be implicated in developing several pathological conditions, including antiretroviral druginduced liver injury (ARVDILI). Notably, GST polymorphisms have been shown to be associated with ARVDILI risk. However, data on GST polymorphisms in the Thai population are limited. Therefore, this study investigated possible associations between GST genetic polymorphisms and ARVDILI development. A total of 362 people living with HIV (PLHIV) and 85 healthy controls from multiple centers were enrolled. GSTM1 and GSTT1 genetic polymorphisms were determined using polymerase chain reactions. In addition, HLA genotypes were determined using a sequence-based HLA typing method. After comparing GST genotypic frequencies, there was no significant difference between PLHIV and healthy volunteers. However, while observing the PLHIV group, GSTT1 wild type was significantly associated with a 2.04-fold increased risk of ARVDILI (95%CI: 1.01, 4.14; p = 0.045). Interestingly, a combination of GSTT1 wild type and HLA-B*35:05 was associated with a 2.28-fold higher risk of ARVDILI (95%CI: 1.15, 4.50; p = 0.02). Collectively, GSTT1 wild type and a combination of GSTT1 wild type plus HLA-B*35:05 were associated with susceptibility to ARVDILI in the Thai population. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.languageen
dc.publisherMDPI
dc.subjectadverse drug reaction
dc.subjectdrug-induced liver injury
dc.subjectgenetic polymorphisms
dc.subjectglutathione s-transferase
dc.subjecthepatotoxicity
dc.subjecthuman immunodeficiency virus
dc.titleThe Association of HLA-B*35 and GSTT1 Genotypes and Hepatotoxicity in Thai People Living with HIV
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationNano Research. Vol , No. (2022), p.-
dc.identifier.doi10.3390/jpm12060940
Appears in Collections:Scopus 2022

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