Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27321
ชื่อเรื่อง: Potassium-competitive acid blockers and gastroesophageal reflux disease
ผู้แต่ง: Leowattana W.
Leowattana T.
Keywords: Esophageal mucosal resistance
Gastroesophageal reflux disease
Potassium-competitive acid blocker
Proton pump inhibitor-refractory patients
Proton pump inhibitors
Treatment outcome
วันที่เผยแพร่: 2022
สำนักพิมพ์: Baishideng Publishing Group Inc
บทคัดย่อ: Proton pump inhibitors (PPIs), the most commonly used antisecretory medications in the management of reflux illness, virtually eliminate elective surgery for ulcer disease, and relegate anti-reflux surgery to patients with gastroesophageal reflux disease (GERD) who are inadequately managed by medical therapy. However, PPI medications still leave some therapeutic demands of GERD unmet. Furthermore, up to 40%-55% of daily PPI users have chronic symptoms, due to PPI refractoriness. Potassium-competitive acid blockers (P-CABs) transcend many of the problems and limits of PPIs, delivering quick, powerful, and extended acid suppression and allowing for treatment of numerous unmet needs. Recently, it has become clear that compromised mucosal integrity plays a role in the etiology of GERD. As a result, esophageal mucosal protection has emerged as a novel and potential treatment approach. An increasing body of research demonstrates that when P-CABs are used as primary drugs or add-on drugs (to regular treatment), they provide a considerable extra benefit, particularly in alleviating symptoms that do not respond to PPI therapy. ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135021857&doi=10.3748%2fwjg.v28.i28.3608&partnerID=40&md5=d142bd901e9ba5253180298047da4aee
https://ir.swu.ac.th/jspui/handle/123456789/27321
ISSN: 10079327
Appears in Collections:Scopus 2022

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