Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27293
ชื่อเรื่อง: Optical Coherence Tomography Features for Identifying Posttreatment Complete Polypoidal Regression in Polypoidal Choroidal Vasculopathy
ผู้แต่ง: Chaikitmongkol V.
Chaovisitsaree T.
Patikulsila D.
Kunavisarut P.
Phasukkijwatana N.
Watanachai N.
Choovuthayakorn J.
Isipradit S.
Boonyot P.
Sangkaew A.
Ingviya T.
Bressler S.B.
Bressler N.M.
Keywords: age-related macular degeneration
complete polypoidal regression
indocyanine green angiography
optical coherence tomography
polypoidal choroidal vasculopathy
วันที่เผยแพร่: 2022
สำนักพิมพ์: Lippincott Williams and Wilkins
บทคัดย่อ: Purpose: To determine accuracy and relative risk (RR) of posttreatment optical coherence tomography (OCT) features in identifying complete or incomplete polypoidal regression in polypoidal choroidal vasculopathy (PCV). Design: Validity analysis. Methods: Treatment-naive PCV eyes undergoing OCT and indocyanine green angiography (ICGA) at baseline and posttreatment were included. Two graders confirmed diagnosis and identified posttreatment complete or incomplete regression on ICGA. Two other graders classified OCT characteristics of pigment epithelial detachment (PED) (polypoidal lesion) based on 5 prespecified features: "A," no PED; "B," PED with internal homogeneous reflectivity with predominant "BUN" (blended retinal pigment epithelium with underlying structure) sign; "C," PED with internal homogeneous reflectivity with minimal "BUN"; "D," heterogeneous PED; and "E," PED with hyporeflectivity. Results: Among 130 polypoidal lesions (65 pretreatment and 65 posttreatment) of 39 PCV eyes (39 patients; 54% female; mean age±SD: 64.6±8.2), all pretreatment lesions showed feature D on OCT. Posttreatment lesions with complete regression (31 lesions) showed OCT features A, B, C, D, and E in 32%, 45%, 13%, 10%, and 0%, respectively. Posttreatment lesions with incomplete regression (34 lesions) showed OCT features A, B, C, D, and E in 0%, 6%, 15%, 79%, and 0%, respectively. Presence of either feature A or B had highest accuracy (86%; 95% confidence interval: 75%-93%); 77% sensitivity; 94% specificity; RR 5.0 (3.5-7.1, P<0.001) for complete regression. Presence of feature D had highest accuracy (85%; 95% confidence interval: 74%-92%); 79% sensitivity; 90% specificity; RR 4.6 (3.0-6.9, P<0.001) for incomplete regression. Conclusions: Without ICGA, OCT features could provide high accuracy in identifying posttreatment complete or incomplete polypoidal regression in PCV. © 2022 Asia-Pacific Academy of Ophthalmology. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139410715&doi=10.1097%2fAPO.0000000000000551&partnerID=40&md5=53fb54a31dc69f477d2b5e221f02bafb
https://ir.swu.ac.th/jspui/handle/123456789/27293
ISSN: 21620989
Appears in Collections:Scopus 2022

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